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Researchers help uncover mechanism behind heart failure and mortality in sepsis

06:22 EDT 7 Sep 2017 | Medical Xpress

Of the nearly one million people in the United States who are affected by sepsis each year, almost one-fifth die. Cardiovascular complications account for approximately 80 percent of those deaths. The heart muscle, weakened by systemic inflammation, is unable to generate the energy it needs to contract, resulting in a severe decline in blood flow and oxygen delivery to tissues that ultimately leads to organ failure. Now, in new work, scientists at the Lewis Katz School of Medicine at Temple University (LKSOM), in collaboration with colleagues at Columbia University in New York, describe the mechanism underlying the loss of energy from heart dysfunction in sepsis, opening the way for the development of a new therapy that could save thousands of lives annually.

Original Article: Researchers help uncover mechanism behind heart failure and mortality in sepsis

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