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In patients with moderate to severe osteoarthritis knee pain, a single intra-articular injection of 1 mg of CNTX-4975 was well tolerated and significantly improved pain with walking, knee stiffness and physical function, according to findings presented at PAINWeek.“As our populations are aging, the number of people suffering from moderate to severe knee osteoarthritis is increasing,” Randall M. Stevens, MD, chief medical officer of Centrexion Therapeutics, told Healio Internal Medicine. “Unfortunately, current treatments — like NSAIDs, opioids or hyaluronic acid and corticosteroid injections — are limited in the level of efficacy they provide, and come with significant side effects that can be serious, especially in older individuals. CNTX-4975 for intra-articular injection has shown substantial promise in clinical trials as a long-lasting and efficacious treatment, with a safety profile that looks similar to that of placebo.”NEXT ARTICLE
Arthritis is by definition the inflammation of one or more joints, characterized by swelling, pain, warmth, redness and diminished range of joint movement (Oxford Medical Dictionary). There are many different types; Noninflammatory; Osteoarthritis, N...
A joint is where two or more bones come together, like the knee, hip, elbow, or shoulder. Joints can be damaged by many types of injuries or diseases, including Arthritis - inflammation of a joint causes pain, stiffness, and swelling with ...
Pain is defined by the International Association for the Study of Pain as “an unpleasant sensory and emotional experience associated with actual or potential tissue damage or described in terms of such damage”. Some illnesses can be excruci...