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A new kind of antifungal drug acts a little like a siege tower, sidling up to the fortifications of infectious organisms, encouraging otherwise reluctant combatants to join the fight. Instead of a stone wall, the antifungal drug encounters the cell wall of a fungus. Instead of archers or spearmen, the drug rallies endogenous antibodies. Ultimately, drugs of this kind, which are called antibody-recruiting molecules targeting fungi (ARM-Fs), mediate engulfment and phagocytosis of the targeted organism. The castle, swarmed by antibodies, brought to the attention of immune cells, and beset on all sides, ultimately falls. Details about the ARM-Fs appeared September 11 in the journal Angewandte Chemie , in an article entitled “Neutralization of Pathogenic Fungi with Small-Molecule Immunotherapeutics.” The article describes how a team of Yale scientists designed, synthesized, and evaluated the antifungal action of the ARM-Fs, which represent a new class of bifunctional molecule. “Our approach ...NEXT ARTICLE
Pharmacy is the science and technique of preparing as well as dispensing drugs and medicines. It is a health profession that links health sciences with chemical sciences and aims to ensure the safe and effective use of pharmaceutical drugs. The scope of...
Antiretroviral Therapy Clostridium Difficile Ebola HIV & AIDS Infectious Diseases Influenza Malaria Measles Sepsis Swine Flu Tropical Medicine Tuberculosis Infectious diseases are caused by pathogenic...
Clinical Approvals Clinical Trials Drug Approvals Drug Delivery Drug Discovery Generics Drugs Prescription Drugs In the fields of medicine, biotechnology and pharmacology, drug discovery is the process by which drugs are dis...