HDAC5 is required for maintenance of pericentric heterochromatin, and controls cell-cycle progression and survival of human cancer cells

05:05 EST 4 Feb 2012 | Nature Publishing

Channels 116 Associated Channels

Checkpoint kinase 1 CHK 1
Progression through the cell cycle is monitored by surveillance mechanisms known as cell cycle checkpoints. Dysfunction in cell cycle checkpoints leads to genomic instability and contributes to tumo...
Polo like kinase Plk 1
Polo-like kinase (Plk) is an important cell cycle regulatory kinase that has been implicated in a multitude of cell cycle events. Plks form a family of four different proteins that regulates many as...
Hypothalamic Controls
Novel Mitotic Kinase Inhibitors
Mitosis, a central event in tumor growth, is highly regulated to ensure accurate and equal segregation of genetic materials from parent cells to daughter cells. Main effectors of this process are mi...
Menstrual Cycle
Remission maintenance
Maintenance therapy
Notch Pathway Inhibitors DLL4
The Notch signaling pathway has been found to play central roles in humans in stem cell maintenance, cell fate decisions, and in cancer as well. Notch family members are being revealed as oncogenes...
Disorders of Calcium Concentration
Calcium (Ca) is required for the proper functioning of muscle contraction, nerve conduction, hormone release, and blood coagulation. In addition, proper Ca concentration is required for various othe...
Ulcerative Colitis
Ulcerative colitis is a disease that affects around 120,000 people in the UK and causes inflammation of the large intestine - or colon. Symptoms vary in severity from pain and discomfort, through mu...