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Biotech Tracker: Crestor Approved 
August 13, 2003 AstraZeneca’s (NYSE: AZN) Crestor (rosuvastatin) has received FDA approval as an adjunct to diet for the treatment of various lipid disorders including primary hypercholesterolemia, mixed dyslipidemia, and isolated hypertriglyceridemia. A clinical outcomes program was initiated in May 2003 that is expected to enroll more than 18,000 patients. We expect this program to generate real-world data substantiating Crestor’s reassuring risk/benefit profile, helping to establish it as the number one threat to sales of Pfizer’s (NYSE: PFE) Lipitor. Crestor and Lipitor are both members of the class of cholesterol-lowering drugs known as statins. 

Crestor’s dose range is 5 to 40 mg once daily with a typical starting dose of 10 mg, and an atypical starting dose of 5 mg for those who require less aggressive lipid profile modulation or who are predisposed to myopathy (the uncomfortable muscular syndrome associated with statin use). The 40 mg dose should be reserved for individuals truly refractory to 20mg, as reflected by failure to achieve target LDL levels.  
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