| December
05, 2003 Human
Genome Sciences’ (NASDAQ: HGSI) LymphoRad-131 is a
radioconjugate in development for multiple myeloma and
non-Hodgkin lymphoma (NHL). The construct has generated
evidence of biological and sub-clinical (surrogate marker)
activity in phase I investigation. Data are slated for
presentation at the American Society of Hematology meeting,
which begins tomorrow in San Diego.
Ongoing,
dose-escalating phase I trials are generating reassuring
pharmacokinetic, pharmacodynamic, dosimetry, and safety
profiles. Associated tolerability and adversity issues appear
predictable and manageable, although uncertainty exists
regarding appropriateness of LymphoRad’s benefit/risk ratio.
Of
6 subjects with relapsed, refractory follicular NHL enrolled
in one investigation, 3 are evaluable at a follow-up of 12
weeks. One patient experienced disease stabilization, one
continued to experience rapidly progressive disease, and one
had a partial response.
LymphoRad-131
is a radioiodinated (I-131) form of recombinant B Lymphocyte
Stimulator (BLyS). BLyS is a B cell maturation factor of the
TNF family that binds selectively to immunoglobulin-positive B
cells. Like Biogen IDEC’s (NASDAQ: BIIB) Zevalin and
Corixa’s (NASDAQ: CRXA) Bexxar, LymphoRad binds to B cells
and B cell tumors, delivering low doses of radiation that can
cause cell death. |
|
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