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Biotech Tracker: HuMax-CD4 Fails for Psoriasis
December 12, 2003 Genmab’s (Copenhagen: GEN) 118-patient, phase II investigation of HuMax-CD4 did not achieve statistically significant results. We previously warned of the high probability of failure in this indication. We reported its poor magnitude of therapeutic effect in a separate phase II psoriasis trial in our December 1, 2003 BT Report. Genmab “has no further plans to develop HuMax-CD4 for the treatment of psoriasis…. Our primary hope for HuMax-CD4 is still cancer.”

HuMax-CD4 is a fully human anti-CD4 monoclonal antibody developed with Medarex (NASDAQ: MEDX). Development for the treatment of rheumatoid arthritis has already been cancelled. In cancer, the construct has begun to show some initial signs of clinically relevant value for the management of cutaneous T cell lymphoma (CTCL), a low-profile indication.

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