CDP870 is a pegylated, anti-TNF-alpha monoclonal antibody fragment. TNF-alpha is a cytokine (small hormone-like protein that transmits signals between cells) important in immune responses and inflammation. Amgen’s (NASDAQ: AMGN) Enbrel, Johnson & Johnson’s (NYSE: JNJ) Remicade, and Abbott’s (NYSE: ABT) Humira are marketed TNF-alpha inhibitors. Celltech shares have been under pressure since mid-November when Pfizer’s (NYSE: PFE) request to re-negotiate the terms of its collaboration with Celltech to develop CDP870 raised further doubts about the viability of the program.

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