In June 2002, Lorus received approval from the Drug Development Group of the Division of Cancer Treatment and Diagnosis, National Cancer Institute (NCI) to conduct several clinical trials of GTI-2040 in a variety of cancers. The FDA has granted the construct orphan drug status for the treatment of advanced renal cell cancer.

GTI-2040 and other antisense molecules being developed by Lorus target a molecular system involved in the manufacture and repair of DNA. RNR catalyzes the formation of deoxyribonucleotides (the building blocks of DNA) by removing an oxygen molecule from the corresponding ribonucleotides. Cancer cells, like all other replicating cells, require RNR activity to produce new DNA. Lorus has developed antisense constructs that can target either of two RNR subunits.

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