Epigenetic News: Breaking Epigenetic News, Comments and Articles. - Page: 3

FORMA Therapeutics and Celgene Corporation Establish Broad Strategic Collaboration to Advance Innovative Drugs Targeting Protein Homeostasis

FORMA Therapeutics Holdings, LLC (FORMA) today announced a strategic collaboration agreement with Celgene Corporation under which FORMA and Celgene will discover, develop and commercialize drug candidates to regulate protein homeostasis targets. Protein homeostasis, which is important in oncology, neurodegenerative and other disorders, involves a...

All you ever wanted to know about Glyphosate, Biosemiotic Entropy, Disorder, Disease, and Mortality but were too afraid to ask.

Reuters have recently highlighted an article about the herbicide glyphosate from a special issue of an online journal entirely devoted to disorder (Entropy).The text of the surprising Reuters post is here:Heavy use of herbicide Roundup linked to health dangers-U.S. study By Carey GillamApril 25 (Reuters) - Heavy use of the world's most popular herbicide, Roundup, could be linked to a range of...

Epizyme, Inc. Files Registration Statement for Proposed Initial Public Offering

CAMBRIDGE, Mass., April 26, 2013 /PRNewswire/ -- Epizyme, Inc., today announced that it has filed a registration statement on Form S-1 with the U.S. Securities and Exchange Commission ("SEC") relating to the proposed initial public offering of its common stock.  The number of shares to be offered and the price range for the offering have not been determined. Citigroup, Cowen and Company, LLC...

[Epizyme] jumps on board; becomes the fourth biotech to file for a US IPO in April

Cancer epigenetics company [Epizyme Inc.] has filed for its initial public offering. The company is the fourth biotech this month to file for an IPO, behind anticoagulant developer [Portola Pharmaceuticals Inc.], plasma-derived therapeutics company [...

What The Heck Does "Epigenetic" Mean, Anyway?

A lot of people (and I'm one of them) have been throwing the word "epigenetic" around a lot. But what does it actually mean - or what is it supposed to mean? That's the subject of a despairing piece from Mark Ptashne of Sloan-Kettering in a recent PN...

The Role Of Epigenetic Influences In Autism

Scientists from King's College London have identified patterns of epigenetic changes involved in autism spectrum disorder (ASD) by studying genetically identical twins who differ in autism traits. The study, published in Molecular Psychiatry, is the...

The Epigenetics Of Pain In Endometriosis

Most of us probably know at least one woman, and maybe quite a few more, with endometriosis. Despite the disease's prevalence, there is no consensus on the cause of it, the existing treatment options leave a lot to be desired, and there are too few w...

Pain, epigenetics and endometriosis

BOSTON — Most of us probably know at least one woman, and maybe quite a few more, with endometriosis. Despite the disease's prevalence, there is no consensus on the cause of it, the existing treatment options leave a lot to be desired, and there ar...

Pain, epigenetics and endometriosis: Research team wants to know how molecular tweaks affect which women hurt the most

Most of us probably know at least one woman, and maybe quite a few more, with endometriosis. Despite the disease's prevalence, there is no consensus on the cause of it, the existing treatment options leave a lot to be desired, and there are too few w...

Grandma's Experiences Leave a Mark on Your Genes

Your ancestors' lousy childhoods or excellent adventures might change your personality, bequeathing anxiety or resilience by altering the epigenetic expressions of genes in the brain.

Epigenetic changes shed light on biological mechanism of autism

(King's College London) Scientists from King's College London have identified patterns of epigenetic changes involved in autism spectrum disorder (ASD) by studying genetically identical twins who differ in autism traits. The study, published in Molec...

NEB Releases CutSmart™ Buffer and Sets New Standard for Restriction Enzyme Convenience and Performance

IPSWICH, Mass., April 22, 2013 /PRNewswire/ -- New England Biolabs (NEB), a leader in the production of reagents for the life science industry, announces the release of CutSmart Buffer. This latest development from NEB supports an industry-leading portfolio of over 200 restriction enzymes that exhibit 100% activity in a single buffer. With CutSmart Buffer, it is significantly easier to s...

Aurigene's Collaboration Programs with Endo Pharmaceuticals Reach Important Milestones

BRIDGEWATER, New Jersey, April 22, 2013 /PRNewswire/ -- Aurigene and Endo entered into collaboration in 2009, for multiple integrated drug discovery programs in the areas of Inflammation and Oncology.      (Logo: http://photos.prnewswire.com/prnh/20130418/608115 ) In one of the programs, a novel selective dual kinase inhibitor, targeting both the antigen receptor signalling...

HDAC-mediated suppression of histone turnover promotes epigenetic stability of heterochromatin

The mechanisms underlying gene silencing and epigenetic stability of heterochromatin are not fully understood. New studies in fission yeast now show that heterochromatin differs from euchromatin in the turnover of histones, and they identify the hist...

N.C. Includes Ag Among Many Biotech Successes

North Carolina’s impressive Pavilion at the BIO 2013 International Convention will feature “Afternoons with AgBiotech” as a specialty stop for the 17,000-plus people attending the April 22 through 25 extravaganza. Monday through Wednesday afternoon, April 22 through 24, BIO 2013 attendees who visit North Carolina’s Pavilion # 2617 a...

Epizyme files for $69M IPO

Epizyme is seeking $69 million in an initial public offering to support its epigenetics platform and personalized cancer therapies. The Cambridge, Massachusetts based company registered its IPO intentions with the US Securities.....

Epigenetics and crop improvement

Figure 1 The phenotype of an organism is controlled through variation in genotype, epigenetics...Author Nathan M. SpringerSummaryThere is considerable excitement about the potential for epigenetic information to contribute to heritable variati

Epizyme to Partner to Develop DOT1L Companion Diagnostic

CAMBRIDGE, Mass., April 18, 2013 /PRNewswire-USNewswire/ -- Epizyme, Inc., a clinical stage biopharmaceutical company creating innovative personalized therapeutics for patients with genetically defined cancers, announced today that it has signed an agreement with Abbott, a global healthcare company, to develop a molecular companion diagnostic test for use with EPZ-5676. EPZ-5676, Epizyme's most ad...

Super-Enhancers in Cell Biology: ENCODE's Revenge?

I've linked to some very skeptical takes on the ENCODE project, the effort that supposedly identified 80% of our DNA sequence as functional to some degree. I should present some evidence for the other side, though, as it comes up, and some may have c...

Resverlogix Completes Dosing In ASSURE Clinical Trial

IVUS data will evaluate plaque regression in patients with high-risk Cardiovascular Disease TSX Exchange Symbol: RVX CALGARY, April 18, 2013 /PRNewswire/ - Resverlogix Corp. (TSX:RVX) today announced that it has completed dosing in ASSURE, a Phase 2b clinical trial evaluating RVX-208, Resverlogix's first-in-class orally active BET-protein inhibitor, using intra-vascular ultrasound (IVUS)...

Aurigene Announces Transition of Multiple Programs to Clinical Development in its Collaboration Business

BRIDGEWATER, New Jersey, April 18, 2013 /PRNewswire/ -- Aurigene has had a number of collaboration programs with large pharma companies over the years, and has reported successes in these programs.      (Logo: http://photos.prnewswire.com/prnh/20130418/608115 ) Elaborating on the successful collaboration programs, Aurigene's CEO CSN Murthy said "Aurigene combines its excell...

NNMT promotes epigenetic remodeling in cancer by creating a metabolic methylation sink

[Resverlogix] hopes to become acquisition target by spinning out [RVX Therapeutics]

In order to focus all efforts on a cardiovascular program that could make the company a strong acquisition candidate, public Canadian biotech [Resverlogix Corp.] will spin out its [RVX Therapeutics Inc.] division into an independent entity that will...

Advancements In Immunotherapy And Epigenetics

A dozen Ludwig scientists from around the world presented the latest advancements in basic and clinical cancer research at the American Association for Cancer Research (AACR) Annual Meeting 2013. Progress in immunotherapy and epigenetics led the prog...

Multiple mechanisms deregulate EZH2 and histone H3 lysine 27 epigenetic changes in myeloid malignancies