Gene Therapy News: Breaking Gene Therapy News, Comments and Articles.

[Comment] A new approach to second-line therapy for urothelial cancer?

Despite responses shown by 40–60% of patients with advanced urothelial carcinoma receiving first-line cisplatin-based combination chemotherapy, disease progression occurs in nearly all patients at a median of about 8 months. Second-line agents are...

[Comment] From mice to man: chloride transport in leukoencephalopathy

In The Lancet Neurology, Christel Depienne and colleagues show that mutations in CLCN2—the gene encoding the chloride channel ClC-2—underlie a specific form of human leukoencephalopathy. This important work confirms in human beings what was previ...

Study: Extended azithromycin therapy may offer significant benefits to COPD patients

Extended use of a common antibiotic may prolong the time between hospitalizations for patients suffering from chronic obstructive pulmonary disease, according to a post-hoc analysis of a multicenter study which compared the hospitalization rates of p...

End Points in Trials of Treatments for Skin Infections

To the Editor: In accord with US Food and Drug Administration guidance for skin infection clinical trials, Dr Prokocimer and colleagues reported an early “cessation of lesion spread” analysis as their primary end point in a trial of tedizolid pho...

Oxygenation Targets and Outcomes in Premature Infants Oxygenation Targets and Outcomes in Premature Infants

Many premature infants experience respiratory failure and receive supplemental oxygen for prolonged periods. While this therapy is crucial for their survival, it can be associated with complications such as retinopathy of prematurity (ROP), bronchopu...

Care for Transgender Persons

To the Editor: The article by Dr Spack concerning the management of persons with gender identity disorders misstated the prerequisites for cross-sex hormone therapy and omitted any explanation of transsexual subtypes. Spack stated that adults should...

Effects of Targeting Higher vs Lower Arterial Oxygen Saturations on Death or Disability in Extremely Preterm Infants A Randomized Clinical Trial Arterial Oxygen Saturation Levels in Preterm Infants

ImportanceThe goal of oxygen therapy is to deliver sufficient oxygen to the tissues while minimizing oxygen toxicity and oxidative stress. It remains uncertain what values of arterial oxygen saturations achieve this balance in preterm infants.Objecti...

Immunotherapy: Adoptive cell therapy simplified

Charged particle therapy—optimization, challenges and future directions

Charged particle therapy (CPT) offers advantages over conventional radiotherapy, such as higher local control of the tumour and the potential for less damage to healthy tissues. Despite the advantages of CPT, only a small number of controlled randomi...

Trigemina to Present at the 13th Annual Pain Therapeutics Conference in London

LONDON, May 20, 2013 /PRNewswire/ -- Trigemina, Inc., a biopharmaceutical company focused on the discovery and development of non-narcotic, nasally delivered, analgesic drug products, today announced that David C. Yeomans, Ph.D., Chief Scientist and Founder, as well as the Director of Pain Research at Stanford University School of Medicine, will be giving two presentations today at the 13th A...

Peritoneal dialysis—current status and future challenges

Peritoneal dialysis is now the most commonly practiced form of home dialysis; however, a number of challenges must be overcome if use of this therapy is to continue to increase. In this Review, Simon Davies discusses the implications of evolving heal...

Viral hepatitis: Carjacking HBV therapy

Colorectal cancer: Is the new era of colorectal cancer classification finally here?

Colorectal cancer is a heterogeneous disease, with at least three well-known major, molecularly defined groups: the chromosomal instable, the microsatellite instable and the CpG island methylator phenotype. Although these groups differ in pathology,...

New Study Shows Effects of Medicinal Mushroom Extract on Pancreatic Cancer Cells

SAN FRANCISCO, May 20, 2013 /PRNewswire/ -- A study published in the June issue of the International Journal of Oncology found that Poria Triterpine Extract (PTE), a mixture of triterpines from Poria cocos, a medicinal mushroom used in traditional Asian medicine, suppress the proliferation of human pancreatic cancer cell lines. Pancreatic cancer has some of the poorest survival rates among...

Sangamo BioSciences Presents New Data From In Vivo Protein Replacement Platform For Development Of ZFP Therapeutics® For Monogenic Diseases

RICHMOND, Calif., May 20, 2013 /PRNewswire/ -- Sangamo BioSciences, Inc. (Nasdaq: SGMO) announced the presentation of new data demonstrating the successful application of Sangamo's proprietary In Vivo Protein Replacement Platform (IVPRP) to produce therapeutically relevant levels of Factor VIII in a mouse model.  Sangamo has partnered with Shire AG (LSE: SHP, NASDAQ: SHPG)...

RNL BIO and Human Biostar to Offer Direct-to-Consumer Adult Stem Cell Banking in the United States

SEOUL, South Korea, May 20, 2013 /PRNewswire/ -- RNL BIO Co. Ltd., a stem cell biotechnology company dedicated to the commercialization of autologous cell therapy products for a variety of degenerative, ischemic and other indications, announces the availability of adult stem cell banking in the United States beginning on June 20, 2013.  RNL BIO previously offered these services through a...

Therapeutic Response in Feline Sandhoff Disease Despite Immunity to Intracranial Gene Therapy

BCL-2 Inhibitors Sensitize Therapy-resistant Chronic Lymphocytic Leukemia Cells to VSV Oncolysis

Workshops Offered To Identify Underlying Challenges That Put Strain On Relationships

Texas Counseling is helping couples sift through the elements that strain their relationships and help develop solutions through their Sexuality and Relationship Workshops and individualized counseling sessions. Dallas, Texas (PRWEB) May 21, 2013 Modern couples have countless strains on their relationships. With the help of Texas Counseling’s Sexuality and Relationship Workshops, couples are le...

European Medicines Agency Validates Gilead’s Marketing Application for Sofosbuvir for the Treatment of Hepatitis C

-- Once-Daily Sofosbuvir will Receive an Accelerated Assessment by EMA; Designation Granted to New Medicines of Major Public Health Interest -- Gilead Sciences, Inc. (Nasdaq: GILD) today announced that the company’s Marketing Authorisation Application (MAA) for sofosbuvir, a once-daily oral nucleotide analogue inhibitor for...

Cell Therapeutics, Inc. Presents at UBS Global Healthcare Conference, May-21-2013 02:30 PM

Cell Therapeutics, Inc. (CTIC) May 21, 2013 2:30 pm ET Executives James A. Bianco - Principal Founder, Chief Executive Officer, President and Executive Director Presentation Unknown Analyst So I'm [indiscernible]. I cover biotech space in Europe for UBS. I just would like to introduce Dr. Blanco, CEO for CTI. So you can have probably a 25 minutes presentation. James A. Bianco Than...

Gene therapeutics developer [bluebird] plans to go public

[Bluebird bio Inc.], developer of gene transfer therapeutics, has filed for its initial public offering.

Gene Patents, Angelina Jolie, and Reality

By Dr. Hans Sauer, J.D., Deputy General Counsel for Intellectual Property, Biotechnology Industry Organization  Angelina Jolie recently announced her personal connection with breast cancer and Myriad’s BRCA genetic test.  While Jolie’s post was...

Top 20 up-and-coming cell and gene therapy influencers

In a growing and rapidly developing stem cells, cell and gene therapy industry, more and more companies are starting to shine and present impressive data [...]

Gene Linked to Lung Fibrosis and Its Survival (CME/CE)

PHILADELPHIA (MedPage Today) -- A common genetic variant increases the risk of pulmonary fibrosis but also predicts better survival in idiopathic cases, researchers found.