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Inpharmatica Announces Chematica(TM) Collaboration with Tibotec Pharmaceuticals Ltd.

Tibotec Pharmaceuticals Ltd. will apply Inpharmatica's Chematica technologies to identify molecular targets for anti-viral compounds

London, UK, 1 August 2005 - Inpharmatica Ltd, a leading provider of drug discovery technologies and services, today announces a collaboration with Tibotec Pharmaceuticals Ltd, a pharmaceutical research and development company dedicated to the discovery and development of innovative drugs for HIV/AIDS and other infectious diseases. Tibotec will use Inpharmatica's Chematica technologies to identify the molecular basis for the actions of compounds shown to have anti-viral activity in cell based assays. Headquartered in Belgium with operations in Ireland and the US, Tibotec is part of Johnson & Johnson.

Inpharmatica's Chematica technologies, including StARLITe(TM) and DrugStore(TM), use Inpharmatica's proprietary databases and know-how to link compounds with putative molecular targets. Tibotec will use this technology to advance drug research projects by identifying molecular targets, screening assays and alternative indications for bioactive compounds discovered at Tibotec. The financial terms of the non-exclusive agreement with Tibotec are not disclosed.

Chematica is an integral component of Inpharmatica's gene-to-candidate technology platform which integrates biology- and chemistry-based drug discovery activities. This platform optimises target selection based on druggability, and enables rapid identification of hits and selection of high quality leads and pre-clinical candidates, which are prioritised on the basis of good drug-like characteristics and clinical indication.

Commenting on the announcement, John Lisle, CEO of Inpharmatica, said:

"This collaboration with Tibotec Pharmaceuticals follows a similar collaboration signed with Novartis in 2004 and confirms that Inpharmatica offers unique approaches to the critical problem of identifying the molecular target bioactive compounds."

About Inpharmatica: www.inpharmatica.com/chematica.htm

Founded in 1998, Inpharmatica uses predictive informatics in genomics, medicinal chemistry and ADME to improve the speed and productivity of drug discovery. The company employs around 100 professionals at its UK locations in London and Cambridge, with business development in North America and Japan. Inpharmatica's unique proprietary technologies and skills are utilised in major discovery laboratories worldwide including Serono, Pfizer, GSK, Novartis, Sanofi-Aventis, P&G Pharmaceuticals, and Daiichi.

Inpharmatica is unique in offering discovery technologies and services which span the full breadth of research from gene through to candidate selection: the core elements are fully integrated, enabling customers to access the full end-to-end technologies, or individual components and services as required.

For more information, please contact:

Andrew Lloyd & Associates
Andrew Lloyd / Heidi Thompson
Tel. +44 1273 675100
allo@ala  / heidi@ala.com

Inpharmatica Ltd
John Lisle, Chief Executive Officer
Tel: +44 (0)20 7074 4600
Dr Vimal Mehta, Sr. VP Business Development
Tel: +1 203 453 6525

 

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