The retinoids: Therapeutic & pharmaceutical opportunities

E Sussex, UK 15th January 2003 --- New LeadDiscovery Dossier. Members of the retinoid family play a role in the modulation of cell metabolism, growth, differentiation, proliferation and apoptosis. Over 30 naturally occurring and synthetic analogs of retinoic acid are now either in development or on the market, targeting diverse clinical conditions ranging from various tumor types to a range of skin conditions, with more recent interest being shown in the retinoids with respect to diabetes and airway inflammation. This 200+ page report will give the reader one of the most current and comprehensive reviews of the molecular biology and pathophysiology of the retinoids, as well as their binding proteins and receptors. The report focuses on oncology offering a background on many forms of cancer and an in depth description of the relationship between the retinoids and tumor progression. The report also describes the RAR/RXR ligands and methodologies used in research, as well as full profiles of retinoid-related molecules in development or on the market

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