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We propose that a low-frequency variant can explain the association between ABCA7 and Alzheimer's disease, and the evidence of loss-of-function mutations in this risk gene suggests that partial loss-of-function of ABCA7 could be a potential pathogene...
Alzheimer's disease has a strong heritable component. Early genetic studies of the molecular basis of Alzheimer's disease led to the discovery of rare (less than one per 10 000 population) and highly penetrant mutations in the genes encoding amyloi...
Travel to Bangladesh to meet the Bedey, a band of river nomads, and their trained macaques, which perform shows and seldom transmit a monkey virus to their handlers.
See how William Beebe and Otis Barton descended to the ocean's depths in an early submersible designed to allow access to the mysterious lifeforms inhabiting the deep sea.
Scientist to Watch Shawn Douglas explains the annual competition he established to introduce students to molecular programming.
Meet the digestive tract-lacking oligochaete that has fueled Max Planck research Nicole Dubilier's interest in symbiosis and marine science.
In Chapter 1, “The Problem,” author Jerry Coyne sets the historical stage for his suggestion that science and religion are not compatible and never will be.
In his bathysphere, William Beebe plumbed the ocean to record-setting depths.
Conflict between science and religion continues, with effects on health, politics, and the environment.
Retiring as a professor, and even shutting down your own lab, doesn’t necessarily mean quitting research.
Finding and recruiting diverse populations for clinical studies
A general guide to collecting and processing saliva
Assistant professor, Cellular and Molecular Pharmacology, University of California, San Francisco. Age: 34
A love of the ocean lured Nicole Dubilier into science; gutless sea worms and their nurturing bacterial symbionts keep her at the leading edge of marine microbiology.
Symbiotic bacteria in Caribbean reef sponges store polyphosphate granules, possibly explaining why phosphorous is so scarce in coral reef ecosystems.
A chance discovery results in the first report of DNA-based gene silencing in an animal.
Nutrient levels in soil don’t add up when food chains combine.
Scientists mutate a mating pheromone and its corresponding receptor in yeast to promote speciation.
Ethical issues attend the creation of animal-human chimeras.
Five species of waterfowl have evolved a variety of adaptations to adjust to the high altitude of South America’s Lake Titicaca.
Historical data sheds new light on the possible causes of southern sea lion decline in the Falkland Islands.
Holding laboratory mice at temperatures lower than those the animals prefer could be altering their physiology and skewing experimental results.
Macaque trainers in Bangladesh are often bitten by their monkeys, but rarely infected by a particular simian retrovirus.
Disease eradication in the 21st century
The eradication of smallpox set the standard for the global elimination of a devastating infectious disease. Will the ongoing polio and guinea worm campaigns be as successful?