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The Affinity ITC and ITC Auto are designed for challenging life science laboratory environments that require high sensitivity and high productivity. The instruments are powerful tools for measuring a wide variety of molecular interactions and bring advanced engineering to all critical aspects of the measurement, ensuring high-quality ITC data. The fully automated, user-selectable system cleaning...
The TESCAN S8000G is a next-generation FIB-SEM. The product delivers good image quality with high contrast, making it suitable for characterising biomaterials and nanostructures with the added ability to perform complex nanoengineering tasks with precision and ease. It marries together the Orage Ga FIB column and the BrightBeam SEM column, which are seamlessly integrated to form an instrument for ...
LONDON (Reuters) - A rise in the use of electronic cigarettes among American adults is linked to a significant increase in the numbers of people quitting smoking, researchers said on Wednesday.
WASHINGTON (Reuters) - Republican U.S. Senate leaders, struggling to keep a seven-year-old promise to end Obamacare, turned their focus on Wednesday to passing a slimmed-down "skinny" repeal measure that would throw the issue into negotiations with t...
In the process of generating stable monoclonal antibody (mAb) producing cell lines, reagents such as Methotrexate (MTX) or Methionine Sulfoximine (MSX) are often used. However, using such selection reagent(s) increases the possibility of having higher occurrence of sequence variants in the expressed antibody molecules due to the effects of MTX or MSX on de novo nucleotide synthesis. Since MSX inhi...
Streptomycetes are exploited for the production of a wide range of secondary metabolites, including antibiotics. Therefore, both academic and industrial research efforts are focused on enhancing production of these precious metabolites. So far, this has been mostly achieved by classical or recombinant genetic techniques, in association with process optimization for either submerged or solid state ...
Heterochromatic DNA domains have important roles in the regulation of gene expression and maintenance of genome stability by silencing repetitive DNA elements and transposons. From fission yeast to mammals, heterochromatin assembly at DNA repeats involves the activity of small noncoding RNAs (sRNAs) associated with the RNA interference (RNAi) pathway. Typically, sRNAs, originating from long noncod...
Small-molecule, biologically active natural products continue to be our most rewarding source of, and inspiration for, new medicines. Sometimes we happen upon such molecules in minute quantities in unique, difficult-to-reach, and often fleeting environments, perhaps never to be discovered again. In these cases, determining the structure of a molecule—including assigning its relative and absolute...
The origin of high-temperature superconductivity in copper oxides and the nature of the ‘normal’ state above the critical temperature are widely debated. In underdoped copper oxides, this normal state hosts a pseudogap and other anomalous features; and in the overdoped materials, the standard Bardeen–Cooper–Schrieffer description fails, challenging the idea that the normal state is a simpl...
Neurons in the brain behave as nonlinear oscillators, which develop rhythmic activity and interact to process information. Taking inspiration from this behaviour to realize high-density, low-power neuromorphic computing will require very large numbers of nanoscale nonlinear oscillators. A simple estimation indicates that to fit 108 oscillators organized in a two-dimensional array inside a chip the...
Newly formed black holes of stellar mass launch collimated outflows (jets) of ionized matter that approach the speed of light. These outflows power prompt, brief and intense flashes of γ-rays known as γ-ray bursts (GRBs), followed by longer-lived afterglow radiation that is detected across the electromagnetic spectrum. Measuring the polarization of the observed GRB radiation provides a direct pr...
Polio has almost been eradicated. A field study demonstrates that a combination of focused science and epidemiology, and community-based integrated health approaches, are required to finish the job.
An innovative combination of chemical synthesis, theory and spectroscopy could simplify determination of the structures of naturally occurring, biologically active molecules, which are often leads for drug discovery. See Letter p.436
A nanoscale magnetic device that mimics the behaviour of neurons has been used to recognize audio signals. Such a device could be adapted to tackle tasks with greater efficiency than conventional computers. See Letter p.428
Replying toN.Fortelny, C. M.Overall, P.Pavlidis & G. V.Cohen FreueNature547, doi:10.1038/nature23293 (2017)In the accompanying Comment, Fortelny et al. present a re-analysis of a particular aspect of our draft
Arising fromM.Wilhelmet al. Nature509, 582–587 (2014); doi:10.1038/nature13319Prediction of protein levels from mRNA levels has long been fraught with unreliability and a lack of precision. However, Wilhelm et al. claimed that
A global success?
US PhD awards hit record high.
Leadership skills need to be nurtured early in a career, say Toddi A. Steelman and Jeffrey J. McDonnell.
Small transgressions can quickly breed resentment among labmates — so be sure to learn the unspoken rules of the lab.
Sergei Kalinin and colleagues discuss the latest developments in manipulating matter at the nanoscale, using beams of electrons in aberration-corrected scanning transmission electron microscopes (STEMs) (Nature539, 485–487;10.1038/539485a2016). Such investigations have a long history of success, hidden
Your report on discussions about a possible location for the Thirty Meter Telescope (TMT) calls for some clarification (Naturedoi.org/b9px (2017); see also Naturedoi.org/b9pz; 2016). Although the TMT board's preferred site is Mauna Kea in Hawaii, the alternative
I agree that we need to consider the diversity of species' functions, particularly those that are crucial for maintaining ecosystems (Nature546, 22–24;10.1038/546022a2017). However, functional diversity alone is not enough if we are to reach global conservation
You err in citing the Swiss National Science Foundation (SNSF) as a funding agency that forbids its grant-holders to use commercial data platforms such as figshare (Nature546, 327;10.1038/546327a2017). The SNSF strongly supports the sharing of data and open
The deposition and sharing of research materials is an often-overlooked but crucial aspect of the debate on open data, even though deposition is straightforward and free of charge (see Nature546, 327;10.1038/546327a2017). Although Nature, for instance, has a clear