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Taxol (paclitaxel) is a diterpenoid compound with significant and extensive applications in the treatment of cancer. The production of Taxol and relevant intermediates by engineered microbes is an attractive alternative to the semichemical synthesis of Taxol. In this study, based on a previously developed platform, we first established taxadiene production in mutant E. coli T2 and T4 by engineerin...
Many of the secrets of cancer and other diseases lie in the cell's nucleus. But getting way down to that level -- to see and investigate the important genetic material housed there -- requires creative thinking and extremely powerful imaging techniques. Vadim Backman and Hao Zhang, nanoscale imaging...
ASLAN Pharma of Singapore is initiating enrollment of the first patient in the Phase I clinical trial for varlitinib (ASLAN001) in biliary tract cancer in Japan. The study is expected to enroll up to 36 Japanese patients. Designed in collaboration with Japanese medical experts, the open-label study is open to all patients with solid tumours and biliary tract cancer. The primary study objectiv...
Hutchison China MediTech (Chi-Med) and AstraZeneca have launched a Phase II study in China of savolitinib (HMPL-504/AZD6094/volitinib), an oral inhibitor targeting c-Met receptor tyrosine kinase for treatment of locally advanced or metastatic pulmonary sarcomatoid carcinoma (PSC). The first drug dose was administered on February 10, 2017. More details....Stock Symbols (AIM/Nasdaq: HCM) ...
Lee’s Pharm acquired Greater China commercialization rights to episil®, a treatment for oral mucositis, from Japan's Solasia Pharma. The agreement does not include Taiwan nor the cities of Beijing, Shanghai or Guangzhou, which Solasia will retain. episil®, an oral liquid that treats the pain associated with oral mucositis, was developed by Camurus of Sweden. Solasia in-licensed right...
Vention Medical has agreed to divest its advanced technology business to Nordson and device manufacturing services business to Medplast.
TEL AVIV (Reuters) - Israel's BrainStorm Cell Therapeutics is seeking early approval in Canada for its adult stem cell treatment for patients with amyotrophic lateral sclerosis (ALS), a neuro-degenerative disease, even before it completes late-stage ...
Listeria, a common food-borne bacterium, may pose a greater risk of miscarriage in the early stages of pregnancy than appreciated, according to researchers at the University of Wisconsin-Madison School of Veterinary Medicine studying how pathogens affect fetal development and change the outcome of pregnancy.
A new digital breast tomosynthesis technique has the potential to reduce the rate at which women are called back for additional examinations without sacrificing cancer detection, according to a new study published online in the journal Radiology.
MRI screening improves early diagnosis of breast cancer in all women-not only those at high risk-according to a new study from Germany published online in the journal Radiology.
(American Association for Cancer Research) Cancer mortality rates vary considerably within the growing Hispanic population in the United States, with significant differences among the major Hispanic ethnic groups.
(New York University) Adolescents with posttraumatic stress disorder (PTSD) symptoms are more likely to misidentify sad and angry faces as fearful, while teens with symptoms of conduct disorder tend to interpret sad faces as angry, finds a study by NYU's Steinhardt School.
(University of Kansas) A new study led by a University of Kansas political scientist found 35 percent-40 percent of adults would oppose a transgender candidate for office, which was higher than the 30 percent who would likely oppose a gay or lesbian candidate.
Lonza now offers cryopreserved lung fibroblasts isolated from donors diagnosed with idiopathic pulmonary fibrosis (IPF) for use in research into this potentially fatal condition. Normal lung fibroblasts and small airway epithelial cells — from both smokers and non-smokers — are also available, offering a complete solution to facilitate IPF and other airway research. Research into IPF is a rap...
Scientific equipment supplier AXT has completed the installation of a TESCAN VEGA SEM at the QIMR Berghofer Medical Research Institute, where it will assist with the institute’s research into cancer, infectious diseases, mental health and chronic disorders. TESCAN VEGA SEMs are robust workhorses capable of producing high-resolution images of biological, materials and mining-related samples. The...
Western Australian researchers have created a new scientific model for the development of type 2 diabetes, which can be caused by the failure of insulin-producing pancreatic beta (β) cells. According to the head of Diabetes Research WA, Professor Grant Morahan, “There’s increasing evidence to suggest that in type 2 diabetes these β cells could be failing because they’re being triggered to...
Frutarom Health reports it will strengthen focus on its phytopharmaceutical business in 2017, following the rapid growth in 2016 The post Frutarom Health increases phytopharmaceutical capacity frutarom strengthen its position in Germany appeared first on PharmaAsia.
New laws are to allow space rocket launches from UK soil - and could even lead to development of new vaccines and antibiotics, the government has said. The Department for Transport thinks space travel will be vital to the fut...
Celgene is to file its potential multiple sclerosis blockbuster ozanimod by the end of the year following phase 3 results showing it outperformed established injectable Avonex. Ozanimod was the main reason why Celgene paid $7...
A small survey suggests that many young sex workers cannot protect themselves from infection and pass it on to their infants.
Five women describe why they used marijuana while pregnant, and how they assessed the risks and benefits before making that choice.
Physicians and providers skeptical of AI should pay close attention to the experience of Mayo Clinic whose top representatives were on hand at HIMSS to describe the benefit of using IBM Watson in clinical trial matching.
Mesoblast is looking at a possible conditional approval pathway in Japan for its cell therapy for rheumatoid arthritis, based on...
Taking the reader from the Victorian era to modern Britain, Psyche on the Skin challenges the idea that self-harm is a phenomenon that can be attributed to 'how we live now'.
Good timing is vital in many situations of daily life, but is rarely something we consider. In a new dissertation from Umeå University in Sweden, Olympia Karampela shows that our ability for timing is something that can be trained and it seems to be connected with our cognitive capacity.