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PKC (Protein Kinase C)

00:34 EDT 22nd September 2017 | BioPortfolio

PKC (protein kinase C) http://www.bioportfolio.com/channels/serine-threonine-protein-kinase-c-pkc is a kinase enzyme and a protein molecule that can change the format of other proteins through chemical reactions called phosphorylation on individual amino acids, specifically serine and threonine amino acids.

By changing the molecular structure of amino acids, and thus whole proteins, PKC can determine the activity status of other proteins and enzymes. These enzymes are all involved in the cell cycle pathway can through synthetic and secretion pathways, can either promote or inhibit apoptosis.

The application of PKC is important, because of the role of apoptosis in cancer and other diseases such as arthritis(http://www.bioportfolio.com/resources/pmarticle/90298/Pkc-Mediates-Tcdd-induced-Apoptosis-Of-Chondrocyte-In-Ros-dependent-Manner.html) and heart disease (http://www.bioportfolio.com/resources/pmarticle/190054/Role-Of-Fat-cd36-In-Novel-Pkc-Isoform-Activation-In-Heart-Of.html).  PKC is also involved in the blood-brain barrier http://www.bioportfolio.com/resources/pmarticle/169131/Activating-Pkc-1-At-The-Blood-brain-Barrier-Reverses-Induction-Of-P.html, differentiation of embroyonic myoblasts (mucle cells) http://www.bioportfolio.com/resources/pmarticle/77083/Pkc-delta-Signalling-Pathway-Is-Involved-In-H9c2-Cells-Differentiation.html and immunological signallying synapses between antigens and T cell receptors in the immune system (http://www.bioportfolio.com/resources/pmarticle/22005/PKC-theta-deficiency-increases-resistance-of-C57BL-6J-mice-to-Plasmodium-berghei.html), meaning that the therapeutic potential of PKC-based compnounds is large. Modulating the effectiveness of PKC itself is a potential approach, but more importantly, it provides us with the information about the structure of the proteins it affects with phosphorylation, allowing scientists to develop similar compounds to modulate their activity.

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