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Public Health Clinical Trials

13:52 EDT 21st September 2017 | BioPortfolio

Secondary Findings From High-throughput Sequencing: How to Announce Them With Respect to the Patient's Needs

High-throughput whole-genome sequencing (WGS) is bringing new opportunities in the diagnosis of rare diseases. It will more frequently lead to a primary diagnosis (aim of the genetic consultation), but it may also lead to the discovery of mutations not related to the patient's disease. These findings are called "incidental findings" (IF) and may give rise to preventive or c...

Qualitative Evaluation of Therapeutic Alliance in Adolescent Psychiatry

Context: Psychiatric disorders (anorexia nervosa, depression, anxiety based school refusal) are a major public health concern in adolescence. Their treatment is a challenge for the families, the health care system and society. The treatment is complex and non-standardized. In clinical practice, the relational dimension between the stakeholders is recognized by all. Neverthe...

Developing E-health Services (DES): The Feasibility and Acceptability of Video-conferencing for Adults With Depression

Depression impacts 1 in 5 people in the United Kingdom and is a significant risk factor for self-harming behaviours and suicide. Research has shown that those experiencing depression may feel embarrassed about seeking help from a health professional and ultimately decide not to seek support at all. This project seeks to give those people an alternative option to face-to-fac...

Development and Assessment of the Implementation of a Collaborative Care Approach for Depression in Primary Care

Depression is one of the most common conditions among primary care patients. Nevertheless, there are several problems in depression diagnosis, clinical management and outcomes. The INDI study, which is based in a collaborative care model, aims to improve the management of depression in primary care patients. It is intended to be implemented in clinical practice within the c...

Peer Administered CBT for PPD

Postpartum depression (PPD) affects up to 20% of women and has profound effects on mothers and their infants. Unfortunately, fewer than 15% of women with PPD receive evidence-based care. This is at least partly due to significant difficulties faced by women in accessing cognitive behavioural therapy (CBT), a preferred 1st line treatment. In Ontario at present, there is a si...

The French E3N Prospective Cohort Study

The French E3N cohort was initiated in 1990 to investigate the risk factors associated with cancer and other major non-communicable diseases in women. The participants were insured through a national health system that primarily covered teachers, and were enrolled from 1990 after returning baseline self-administered questionnaires and providing informed consent. The cohort...

Implementation of Medical Weight Management by Telemedicine

As the prevalence and associated healthcare costs of obesity continue to increase, the need for obesity treatments that contribute to weight loss maintenance are needed. Through the functionality of a smart device, telehealth can provide quality healthcare to individuals of different socioeconomic communities, expand healthcare access, as well as reduce overall healthcare c...

Joyful Parenting Pilot Project RCT Study

Aims: To enhance mental well-being of adolescents, adults and their families by creating a positive, happy and joyful environment in the community. Targets: Parents aged 12-59 and their family members in Hong Kong. Methods: Joyful Parenting Pilot Project will adopt the public health and family-focused approach, under the brand name of "Joyful@HK Campaign". Evidence-based ...

RIPE vs RIPE Plus N-acetylcysteine in Patients With HIV/TB Co-infection: a Randomized Clinical Trial

Although tuberculosis is a treatable disease, it is currently the infectious disease with the highest mortality in the world. It is estimated that one-third of the world's population is infected. HIV is the main predisposing factor for TB development. The Brazilian Ministry of Health and the World Health Organization recommends that patients should initially be treated oral...

Association Analysis for Chronic Diseases Based on Resident Health Records by Using Big Data Methods

This is an observational study to analysis the association factors for common diseases, including chronic obstructive pulmonary disease, coronary artery disease, hypertension, diabetes etc, based on resident healthcare records. More than 10 million resident healthcare records should be collected for the associations study by using big data methods.

The Safety and Efficacy of Nexalin Trans-cranial Electrical Stimulation Stimulation for the Treatment of Depression

The purpose of this research study is to determine whether Nexalin Trans-cranial Electrical Stimulation (TES) is an effective treatment for depression among patients who are candidates for ECT. We also want to know whether Nexalin could be an alternative to ECT. Although Nexalin has been approved for use in the US, using Nexalin to treat depression in this way is investigat...

Gamified WellWe-intervention to Promote the Health and Wellbeing of Families With Small Children

The study evaluates the effectiveness of the WellWe-intervention in promotion of parental self-efficacy for healthy behaviors and mindfulness in parenting from the perspective of families. Aim is also to evaluate the effectiveness of the WellWe-intervention in facilitation of family-centered approach of the health visit in Child health clinic perceived by the families and P...

Management of Health-Related QoL Impairment, Including Pain, Depression and Anxiety, in People With Haemophilia A and B

The puropse of this non-interventional register and survey study is to identify the patterns of prescribed pain, anti-depressive and anti-anxiety medication and management of pain, depression and anxiety for people with haemophilia. The study will be conducted in the Nordic countries (Sweden, Norway, Denmark, Finland) and the aim is to cover the entire haemophilia populatio...

Maternal Autoimmune Disease Research Alliance (MADRA) Registry

This multi-site registry, centered at Duke University, will enroll pregnant women with autoimmune and rheumatologic diseases. The main goal of MADRA is to identify ways to improve the health of women with rheumatic diseases and their babies during pregnancy. Prior studies demonstrate the importance of increase inflammation prior to and during pregnancy on these outc...

A Randomized Controlled Trial to Evaluate the Health Outcomes of Patients With Stable Chronic Disease Managed With a Healthcare Kiosk

A global rise in the prevalence of chronic disease has led to an increase in the demand for primary healthcare services and a shortage of primary care physicians. Addressing these challenges calls for innovations in the healthcare delivery model including greater use of healthcare technology tools. We have previously described the feasibility of using an automated healthcar...

Effect of Antibiotics on Gut Microbiome and Plasma Metabolome

In recent years it has been observed that the gut microbiome can produce metabolites into systemic circulation and thus have important health effects even outside the gastrointestinal system. These metabolites may play a role in the pathogenesis of common public health problems such as diabetes, obesity and cardiovascular disorders. Modern techniques of mass spectrometry-ba...

Internet-delivered Interventions for Stress, Anxiety and Depression in the Workplace

The research will utilise an open feasibility parallel groups trial to examine the impact of novel internet-delivered cognitive behavioural therapy (CBT) interventions for stress, anxiety, and depression compared to treatment as usual (face to face counselling and psychotherapy) in an employment context. Participants will consist of employees accessing services provided by ...

Mixed Methods Study Web-based Life Support Decision Aid

Patients and families want to be involved in healthcare decisions [1]. When the decision-making process does not engage older patients and their families, the care provided does not match patient preferences or meet their needs [2]. Healthcare teams can collaborate to support patients and families facing difficult healthcare decisions, such as decisions about the use of tec...

Importance of Dosing Regimen for the Effect of Vitamin D Supplementation

Vitamin D is a hormone with effects not only on the skeleton, but on most tissues in the body. Lack of vitamin D is associated with cardio-vascular disease (CVD), type 2 diabetes, cancer, infectious and immunological diseases, as well as risk factors for these diseases. However, intervention studies with vitamin D have been inconclusive regarding diseases and risk factors. ...

Pharmacogenomic Testing in Primary Care for the Treatment of Depression

This is a 6-month randomized, wait-listed, controlled pilot trial conducted in 6 department of family medicine (DFM) clinics at the University of Michigan (UM). Physicians practicing at a UM DFM clinical site who are willing to utilize pharmacogenomic (PGx) test results for the management of depression will be enrolled. Patients of these DFM physicians who are adults with a...

Evaluation of Metacognitive Training for Depression (D-MCT) in Outpatient Care

Aim of the current study is to investigate the acceptance and efficacy of Metacognitive Training for Depression (D-MCT) compared to cognitive remediation in outpatients with major depressive disorders in a randomized, controlled, assessor-blind, group trial.

A Behavioral Intervention for Depression and Chronic Pain in Primary Care

Chronic pain and depression frequently co-exist in late and mid-life and contribute to increased disability, high health care costs, psychiatric comorbidity, and suicide. The investigators will recruit 60 adults from two randomly assigned large WCMA primary care practices; one practice will offer Relief (a 9 session behavioral intervention) and the other will offer referral...

MINDFUL-PC: Integrating Mindfulness Into the Patient-Centered Medical Home

Among primary care patients, compare the effectiveness of an 8-week mindfulness-based intervention (Mindfulness Training for Primary Care[MTPC]) vs. a low-dose mindfulness introduction comparator on self-management of chronic illness and illness-related health behavior action plan initiation, as well as on measures related to anxiety, depression, and stress.

Depression & Insulin Sensitivity in Adolescents

There has been a rise in type 2 diabetes (T2D) rates in adolescents, disproportionately in girls from disadvantaged racial/ethnic groups. This group of girls also is at heightened risk for depression, and depression and T2D are linked. Depressive symptoms are a risk factor for worsening of insulin sensitivity, one if the major precursors to T2D. In preliminary studies, the ...

Recovering From Intimate Partner Violence Using Strengths and Empowerment (RISE)

Intimate partner violence (IPV) is a major health concern for women Veterans. IPV is associated with numerous physical and mental health conditions. VHA is implementing IPV screening programs to identify female patients who experience past-year IPV. Despite strong evidence that screening increases detection of IPV, less is established about how to intervene following IPV di...

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