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Losartan Potassium and Hydrochlorothiazide Tablets, USP | Losartan Potassium and Hydrochlorothiazide

12:22 EDT 21st May 2013 | BioPortfolio
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IMAGE losartanhctz-str1.jpgIMAGE losartanhctz-str2.jpg
 
   Losartan Potassium and    
   Hydrochlorothiazide   
(n=858)
   Placebo   
   (n=173)   
   Body as a Whole
 
 
      Abdominal pain
1.2
0.6
      Edema/swelling
1.3
1.2
   Cardiovascular
 
 
      Palpitation
1.4
0
   Musculoskeletal
 
 
      Back pain
2.1
0.6
   Nervous/Psychiatric
 
 
      Dizziness
5.7
2.9
   Respiratory
 
 
      Cough
2.6
2.3
      Sinusitis
1.2
0.6
      Upper respiratory infection 
6.1
4.6
   Skin
 
 
       Rash
1.4
0
Study 1Demographics = (89% Caucasian, 64% female)
   HCTZ   
   Losartan   
   Lisinopril   
Cough
   25%   
   17%   
   69%   
Study 2Demographics = (90% Caucasian, 51% female)
   Placebo   
   Losartan   
   Lisinopril   
Cough
   35%   
   29%   
   62%   
IMAGE losartanhctz-fig1.jpgIMAGE losartanhctz-fig2.jpgIMAGE losartanhctz-fig3.jpg

Manufacturer

NorthStar Rx LLC

Active Ingredients

Source

Drugs and Medications [ 622 Associated Drugs and Medications listed on BioPortfolio]

Losartan potassium and hydrochlorothiazide [Greenstone LLC]

losartan potassium and hydrochlorothiazide tablets, USP

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Losartan Potassium and Hydrochlorothiazide Tablets, USP

Losartan potassium [Aurobindo Pharma Limited]

Losartan Potassium Tablets USP

Losartan potassium [Greenstone LLC]

Losartan potassium and hydrochlorothiazide [Sandoz Inc.]

SANDOZLosartan Potassium and Hydrochlorothiazide Tablets 50/12.5 mgLosartan Potassium and Hydrochlorothiazide Tablets 100/12.5 mgLosartan Potassium and Hydrochlorothiazide Tablets 100/25 mg

Clinical Trials [ 327 Associated Clinical Trials listed on BioPortfolio]

Hydrochlorothiazide (+) Losartan Potassium vs. Amlodipine Comparative Study

An efficacy and safety study of hydrochlorothiazide (+) losartan potassium compared to amlodipine at week 12 in Korean patients with essential hypertension

Bioequivalency Study of Losartan Potassium/Hydrochlorothiazide 100 mg /25 mg Tablet Under Fed Conditions

The objective of this study was to prove the bioequivalence of losartan potassium/hydrochlorothiazide 100/25 mg tablet under fed conditions.

An Open Label Study to Assess the Efficacy, Safety and Tolerability of COZAAR Plus (Losartan Potassium 50mg/Hydrochlorothiazide 12.5mg) Possibly Titrated up to COZAAR Plus-F (Losartan Potassium 100mg/Hydrochlorothiazide 25mg) in Patients With Essential Hy

Evaluate blood pressure after 6 weeks of treatment with COZAAR plus.

A Study of Losartan Compared to Losartan/HCTZ in Pediatric Patients With Hypertension

The purpose of this study is to test the safety and effectiveness of Losartan as compared to Losartan/HCTZ in pediatric patients (6 to 17 years) with high blood pressure.

LAAS (Losartan Anti-Atherosclerosis Study)

The primary objective of this study is to evaluate efficacy, arterial stiffness measured by PWV of Losartan potassium group compared to Carvedilol group after 24 weeks of treatment in pati...

PubMed Articles [ 1773 Associated PubMed Articles listed on BioPortfolio]

Losartan/hydrochlorothiazide combination vs. high-dose losartan in patients with morning hypertension-a prospective, randomized, open-labeled, parallel-group, multicenter trial.

The treatment of morning hypertension has not been established. We compared the efficacy and safety of a losartan/hydrochlorothiazide (HCTZ) combination and high-dose losartan in patients with morning...

Anti-Inflammatory Effects of Anti-Hypertensive Agents: Influence on Interleukin-1β Secretion by Peripheral Blood Polymorphonuclear Leukocytes from Patients with Essential Hypertension.

The effects of clinically relevant concentrations of anti-hypertensive agents on lipopolysaccharide (LPS)-induced interleukin-1beta (IL-1β) secretion by polymorphonuclear leukocytes (PMNs) were inves...

Rheological investigation and its correlation with permeability coefficient of drug loaded carbopol gel: influence of absorption enhancers.

Context: The present study was planned to investigate the effect of absorption enhancers on the microstructure of Losartan potassium gel and hence its influence on the diffusion of Losartan potassium...

Effects of a Fixed Combination of Losartan With Hydrochlorothiazide on Glucose Tolerance in Hypertensive Patients Uncontrolled with Angiotensin II Receptor Blockers Alone.

Aim: The concomitant use of angiotensin II receptor blocker (ARB) with low doses of hydrochlorothiazide (HCTZ) may provide additional antihypertensive activity. HCTZ induces hypokalemia and hyperglyce...

Spectrofluorimetric Assessment of Hydrochlorothiazide Using Optical Sensor Nano-Composite Terbium Ion Doped in Sol-Gel Matrix.

A new, simple, sensitive and selective spectrofluorimetric method for the determination of Hydrochlorothiazide was developed in acetonitrile at pH 6.2. The Hydrochlorothiazide can remarkably enhance t...

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