These highlights do not include all the information needed to use metoprolol succinate extended-release tablets safely and effectively. See full prescribing information for metoprolol succinate extended-release tablets. Metoprolol Succinate Extended-Relea | METOPROLOL SUCCINATE
WARNING: ISCHEMIC HEART DISEASE: Following abrupt cessation of therapy with certain beta-blocking agents, exacerbations of angina pectoris and, in some cases, myocardial infarction have occurred. When discontinuing chronically administered metoprolol succinate extended-release tablets, particularly in patients with ischemic heart disease, the dosage should be gradually reduced over a period of 1 - 2 weeks and the patient should be carefully monitored. If angina markedly worsens or acute coronary insufficiency develops, metoprolol succinate extended-release tablets administration should be reinstated promptly, at least temporarily, and other measures appropriate for the management of unstable angina should be taken. Warn patients against interruption or discontinuation of therapy without the physician’s advice. Because coronary artery disease is common and may be unrecognized, it may be prudent not to discontinue metoprolol succinate extended-release tablets therapy abruptly even in patients treated only for hypertension (5.1).
|
|
Metoprolol succinate extended-release tablets n=1990% of patients |
Placebo n=2001% of patients |
|---|---|---|
| Dizziness/vertigo |
1.8 |
1.0 |
| Bradycardia |
1.5 |
0.4 |
| Accident and/or injury |
1.4 |
0.8 |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
| Tablet |
Shape |
Debossed |
Bottle of 30 NDC 64679- |
Bottle of 100 NDC 64679- |
Bottle of 500 NDC 64679- |
Unit Dose Packages of 100 NDC 64679- |
| 25 mg* |
Oval |
W and 34 |
734-01 |
734-02 |
734-03 | 734-05 |
| 50 mg |
Circular, beveled edge |
W 735 |
735-01 |
735-02 |
735-03 | 735-05 |
| 100 mg |
Circular, beveled edge | W 736 |
736-01 |
736-02 |
736-03 | 736-05 |
| 200 mg |
Oval, beveled edge | W 737 |
737-01 |
737-02 |
737-03 | 737-05 |
Manufacturer
Active Ingredients
Source
- U.S. National Library of Medicine
- DailyMed
- Last Updated: 4 May 2013
Drugs and Medications
Metoprolol succinate [WOCKHARDT USA LLC]
These highlights do not include all the information needed to use metoprolol succinate extended-release tablets safely and effectively. See full prescribing information for metoprolol succinate extend...
Metoprolol succinate [Med-Health Pharma, LLC]
Metoprolol succinate [NCS HealthCare of KY, Inc dba Vangard Labs]
These highlights do not include all the information needed to use metoprolol succinate extended-release tablets safely and effectively. See full prescribing information for metoprolol succinate extend...
Metoprolol succinate [Major Pharmaceuticals]
These highlights do not include all the information needed to use metoprolol succinate extended-release tablets safely and effectively. See full prescribing information for metoprolol succinate extend...
Metoprolol tartrate [Legacy Pharmaceutical Packaging]
Metoprolol Tartrate Tablets, USP
Clinical Trials
This is an open-label, non-comparative, multi-centre clinical study to evaluate the Efficacy and safety of Metoprolol Succinate prolonged-release tablet (Betaloc Zok) in patients with mild...
Enoximone Plus Extended-Release Metoprolol Succinate in Subjects With Advanced Chronic Heart Failure
Beta-blocker medications have been shown to improve heart function and prolong the lives of patients with chronic heart failure (CHF). Some people with advanced CHF have difficulty taking...
This was a 52-week, multicenter, open-label study to determine the safety, tolerability and pharmacokinetics of TOPROL-XL (metoprolol succinate) extended-release tablets (metoprolol CR/XL)...
A Randomized Clinical Trial of Metoprolol in Participants With Mitral Regurgitation.
Mitral valve regurgitation (leakage of the mitral valve of the heart) is frequent and currently there is no specific medical therapy. Mitral regurgitation is a slowly progressive disease...
Pharmacodynamic Study of Carvedilol Versus Metoprolol in Heart Failure
Metoprolol succinate is a beta1-selective beta-blocker, becoming non-selective at higher doses, while carvedilol is non-selective. We examined whether metoprolol remained beta1-selective...
PubMed Articles
Tablet splitting: Product quality assessment of metoprolol succinate extended release tablets.
Metoprolol succinate extended release tablets comprise a multiple unit system containing metoprolol succinate in a multitude of controlled release pellets. Each pellet acts as a separate drug delivery...
Pulsatile multiparticulate drug delivery system for metoprolol succinate.
Cardiovascular diseases and their treatment pose a great challenge. Many instances of cardiovascular disease occur in the early morning hours. Hence, the objective of this study was to develop a time-...
OBJECTIVE: To investigate the effect of metoprolol succinate sustained-release tablets on cardiac function, serum vascular endothelial growh factor (VEGF) and C-reactive protein (CRP) in elderly hyper...
The occurrence of cerebral ischemia is prevalent in patients with hypertension and the combination drug therapy is needed. Thus, the pharmacokinetic interaction between metoprolol (anti-hypertension d...
Abstract Aim. To compare two strengths of a fixed drug combination (FDC) containing metoprolol XL and amlodipine (metoprolol/amlodipine 50/5; and metoprolol/amlodipine 25/2.5) with its components in...
