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Latest Biotechnology, Pharmaceutical and Healthcare PubMed Articles

01:35 EDT 1st September 2016 | BioPortfolio

The development of a useful methodology for simple, scalable, and transformative automation of oligosaccharide synthesis that easily interfaces with existing methods is reported. The automated synthesis can now be performed using accessible equipment where the reactants and reagents are delivered by the pump or the autosampler and the reactions can be monitored by the UV detector. The HPLC-based p...

Reduction of factor XI (FXI) by Protein disulfide isomerase (PDI) was shown to enhance FXI ability to cleave its chromogenic substrate. Three disulfide bonds in FXI (Cys118-Cys147, Cys362-Cys482 and Cys321-Cys321) are involved in this augmented activation.

[This corrects the article DOI: 10.1371/journal.pone.0160091.].

In this work, the effective fluorescence quenching ability of polydopamine nanotubes (PDANTs) towards various fluorescent dyes was studied and further applied to fluorescent biosensing for the first time. The PDANTs could quench the fluorophores with different emission frequencies, aminomethylcoumarin acetate (AMCA), 6-carboxyfluorescein (FAM), 6-carboxytetramethylrhodamine (TAMRA) and Cy5. All th...

Little is known about differences in mental health comorbidity and quality of life in individuals with social anxiety disorder (SAD) according to the number and the types of feared situations.

Au-Pd nanocrystals are an intriguing system to study the integrated functions of localized surface plasmon resonance (LSPR) and heterogeneous catalysis. Gold is both durable and can harness incident light energy to enhance the catalytic activity of another metal, such as Pd, via the SPR effect in bimetallic nanocrystals. Despite the superior catalytic performance of icosahedral (IH) nanocrystals c...

Staphylococcus lugdunensis is a coagulase negative bacterial pathogen that is particularly associated with severe cases of infectious endocarditis. Unique amongst the coagulase-negative staphylococci, S. lugdunensis harbors an iron regulated surface determinant locus (isd). This locus facilitates the acquisition of heme as a source of nutrient iron during infection and allows iron limitation cause...

The probability distribution for the free energy of directed polymers in random media (DPRM) with uncorrelated noise in d=1+1 dimensions satisfies the Tracy-Widom distribution. We inquire if and how this universal distribution is modified in the presence of spatially correlated noise. The width of the distribution scales as the DPRM length to an exponent β, in good (but not full) agreement with p...

In this Rapid Communication we express the partition function of the integrable elliptic solid-on-solid model with domain-wall boundary conditions as a single determinant. This representation appears naturally as the solution of a system of functional equations governing the model's partition function.

Quantum work is usually determined from two projective measurements of the energy at the beginning and at the end of a thermodynamic process. However, this paradigm cannot be considered thermodynamically consistent as it does not account for the thermodynamic cost of these measurements. To remedy this conceptual inconsistency we introduce a paradigm that relies only on the expected change of the a...

We develop a numerical test of hyperbolicity of chaotic dynamics in time-delay systems. The test is based on the angle criterion and includes computation of angle distributions between expanding, contracting, and neutral manifolds of trajectories on the attractor. Three examples are tested. For two of them, previously predicted hyperbolicity is confirmed. The third one provides an example of a tim...

We propose a versatile "stabilization on demand" method for the suppression of modulation instability in oscillatory spatially extended nonlinear systems, based on a genetically optimized multifrequency spatiotemporal modulation of the potential. The method, which ensures full stabilization even for very strong nonlinearities, forms a powerful tool allowing for an arbitrary design of the instabili...

To demonstrate that phase separation is a main mechanism of pattern formation for one of the spatiotemporal patterns emerging in the Ag and Sb electrodeposition system, I performed numerical simulations to model the mixed system of conductive and insulative materials under a steady electric field. For such a dissipative system, I derived the extended Cahn-Hilliard equation using Onsager's variatio...

While the existence of stable knotted and linked vortex lines has been established in many experimental and theoretical systems, their existence in oscillatory systems and systems with nonlocal coupling has remained elusive. Here, we present strong numerical evidence that stable knots and links such as trefoils and Hopf links do exist in simple, complex, and chaotic oscillatory systems if the coup...

The entanglement and localization in eigenstates of strongly chaotic subsystems are studied as a function of their interaction strength. Excellent measures for this purpose are the von Neumann entropy, Havrda-Charvát-Tsallis entropies, and the averaged inverse participation ratio. All the entropies are shown to follow a remarkably simple exponential form, which describes a universal and rapid tra...

Nematic elastomers and glasses are solids that display spontaneous distortion under external stimuli. Recent advances in the synthesis of sheets with controlled heterogeneities have enabled their actuation into nontrivial shapes with unprecedented energy density. Thus, these have emerged as powerful candidates for soft actuators. To further this potential, we introduce the key metric constraint wh...

We investigate the onset of intermittency for vibrating elastic plate turbulence in the framework of the weak wave turbulence theory using a numerical approach. The spectrum of the displacement field and the structure functions of the fluctuations are computed for different forcing amplitudes. At low forcing, the spectrum predicted by the theory is observed, while the fluctuations are consistent w...

It is shown that direct-drive implosions on the OMEGA laser have achieved core conditions that would lead to significant alpha heating at incident energies available on the National Ignition Facility (NIF) scale. The extrapolation of the experimental results from OMEGA to NIF energy assumes only that the implosion hydrodynamic efficiency is unchanged at higher energies. This approach is independen...

We have performed spectrally resolved x-ray scattering measurements on highly compressed polystyrene at pressures of several tens of TPa (100 Mbar) created by spherically convergent shocks at the National Ignition Facility. Scattering data of line radiation at 9.0 keV were recorded from the dense plasma shortly after shock coalescence. Accounting for spatial gradients, opacity effects, and source...

Kramers' rate for the passage of trajectories X(t) over an energy barrier due to thermal or other fluctuations is usually associated with additive noise. We present a generalization of Kramers' rate for systems with multiplicative noise. We show that the expression commonly used in the literature for multiplicative noise is not correct, and we present results of numerical integrations of the Lange...

The effective one-dimensional description of diffusion in two-dimensional channels of varying cross section is revisited. The effective diffusion coefficient D(x), extending Fick-Jacobs equation, depending on the longitudinal coordinate x, is derived here without use of scaling of the transverse coordinates. The result of the presented method is an integral formula for D(x), calculating its value ...

In this paper we exactly solve, within the grand canonical ensemble, a minimal spin model with the hybrid phase transition. We call the model diffusion based because its Hamiltonian can be recovered from a simple dynamic procedure, which can be seen as an equilibrium statistical mechanics representation of a biased random walk. We outline the derivation of the phase diagram of the model, in which ...

Lévy walks define a fundamental concept in random walk theory that allows one to model diffusive spreading faster than Brownian motion. They have many applications across different disciplines. However, so far the derivation of a diffusion equation for an n-dimensional correlated Lévy walk remained elusive. Starting from a fractional Klein-Kramers equation here we use a moment method combined wi...

We study the dynamical evolution toward steady state of the stochastic nonequilibrium model known as the totally asymmetric simple exclusion process, in both uniform and nonuniform (staggered) one-dimensional systems with open boundaries. Domain-wall theory and numerical simulations are used and, where pertinent, their results are compared to existing mean-field predictions and exact solutions whe...

Statistical systems composed of atoms interacting with each other trough nonintegrable interaction potentials are considered. Examples of these potentials are hard-core potentials and long-range potentials, for instance, the Lennard-Jones and dipolar potentials. The treatment of such potentials is known to confront several problems, e.g., the impossibility of using the standard mean-field approxim...

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