Latest Biotechnology, Pharmaceutical and Healthcare PubMed Articles

06:32 EST 20th December 2014 | BioPortfolio

Hydrometallation of iPr2 NGe(CMe3 )(CCCMe3 )2 with HM(CMe3 )2 (M=Al, Ga) affords alkenyl-alkynylgermanes in which the Lewis-acidic metal atoms are not coordinated by the amino N atoms but by the α-C atoms of the ethynyl groups. These interactions result in a lengthening of the GeC bonds by approximately 10 pm and a comparably strong deviation of the GeCC angle from linearit...

The effect of high-pressure and/or high-temperature on the glycation of model protein (ubiquitin) was investigated by mass spectrometry. We report the impact of a high pressure (up to 1200 MPa) on the modification of a ubiquitin using ESI-MS measurements. The application of glucose labelled with stable isotope allows a quantitative assessment of modification under the conditions of high-pressure (...

Assessment of risk and early diagnosis of Alzheimer's disease (AD) is a key to its prevention or slowing the progression of the disease. Previous research on risk factors for AD typically utilizes statistical comparison tests or stepwise selection with regression models. Outcomes of these methods tend to emphasize single risk factors rather than a combination of risk factors. However, a combinatio...

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Added: 2014-10-01 08:00:00

On February 2, 2012, the National Cancer Institute (NCI) sponsored a 2-day workshop with the NCI Thoracic Malignancies Steering Committee and the Food and Drug Administration to bring together leading academicians, clinicians, industry and government representatives to identify challenges and potential solutions in the clinical development of novel targeted therapies for lung cancer. Measures of s...

Dacomitinib (PF-00299804), an irreversible pan-human epidermal growth factor receptor ([HER]-1/EGFR, HER-2, and HER-4) tyrosine kinase inhibitor, demonstrated antitumor activity in Western patients with non-small-cell lung cancer (NSCLC) at a dose of 45 mg once daily. We report data from a phase I/II, multicenter, open-label study of Korean patients with refractory KRAS wild-type adenocarcinoma NS...

The vast majority of non-small-cell lung cancers (NSCLCs) presents as advanced disease, and histological diagnosis is widely based on small samples. The differential activity and toxicity profile of new cytotoxic and molecular-targeted therapies according to histotypes requires a precise subtyping of NSCLC. Immunohistochemistry (IHC) contributes to define the most probable histotype; however, the ...

Acute effects of incidental cardiac irradiation in patients treated for thoracic cancer are not well characterized. We evaluated longitudinal changes in cardiac biomarkers for patients undergoing conformal radiation therapy (RT) with thoracic malignancies with high-dose cardiac exposure.

Thymidine kinase 1 (TK1) is a metabolic enzyme involved in DNA synthesis. Most standard treatment protocols for lung cancer (LC) include cytotoxic agents, which are potential modulators of TK1. We aimed to assess the prognostic significance of serum TK1 activity and its role in monitoring chemotherapy in LC patients.

Our knowledge of thymic malignancies has largely been derived from small, single-institution series. Recognition of the need for broad collaboration led to the creation of the International Thymic Malignancy Interest Group (ITMIG) and the development of a large, centralized database to advance knowledge of these rare tumors.

Definitive radiotherapy treatment of thoracic tumors may be hampered by poor tumor visualization on radiological imaging and the effects of tumor motion. Fiducial markers act to enhance tumor visualization and tracking. Traditional solid fiducial markers, however, may result in complications, particularly in proximal lung lesions. These complications may be mitigated through the use of a liquid fi...

Understanding the interactions of water with atmospheric aerosols is crucial for determining the size, physical state, reactivity and climate impacts of this important component of the Earth's atmosphere. Here we show that water uptake and hygroscopic growth of multi-component atmospherically-relevant particles can be size dependent when comparing 100 nm versus ca. 6 μm sized particles. It was de...

The use of carbonyl-stabilised ammonium ylides to access chiral glycidic amides and the corresponding aziridines has so far been limited to racemic trans-selective protocols. We herein report the development of an asymmetric approach to access such compounds with high levels of stereoselectivity using easily accessible chiral auxiliary-based ammonium ylides. The use of phenylglycinol as the chiral...

The aim of this study was to explore mechanisms by which fructus Schisandrae chinensis (Wuweizi) is able to reveal its protective capacity against hepatocyte injury.

Metal-based nanoparticles (MNPs) may be translocated and biochemically modified in vivo, which may influence the fate of MNPs in the environment. Here, synchrotron-based techniques were used to investigate the behavior of CuO NPs in rice plants exposed to 100 mg/L CuO NPs for 14 days. Micro X-ray fluorescence (μ-XRF) and micro X-ray absorption near edge structure (μ-XANES) analysis revealed th...

Many species of terrestrial fungi produce fruiting bodies that contain high proportions of arsenobetaine (AB), an arsenic compound of no known toxicity. It is unknown whether fungi produce or accumulate AB from the surrounding environment. The present study targets the vegetative life stage (mycelium) of fungi, to examine the role of this stage in arsenic transformations and potential formation of...

We studied the colonization of ectomycorrhizal fungi and species abundance of a hybrid larch (F1) under elevated CO2 and O3. Two-year-old seedlings were planted in an Open-Top-Chamber system with treatments: Control (O3 

The human habitat is a host where microbial species evolve, function, and continue to evolve. Elucidating how microbial communities respond to human habitats is a fundamental and critical task, as establishing baselines of human microbiome is essential in understanding its role in human disease and health. Recent studies on healthy human microbiome focus on particular body habitats, assuming that ...

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