Bioactive ceramic-reinforced composites for bone augmentation.
Summary of "Bioactive ceramic-reinforced composites for bone augmentation."
Biomaterials have been used to repair the human body for millennia, but it is only since the 1970s that man-made composites have been used. Hydroxyapatite (HA)-reinforced polyethylene (PE) is the first of the 'second-generation' biomaterials that have been developed to be bioactive rather than bioinert. The mechanical properties have been characterized using quasi-static, fatigue, creep and fracture toughness testing, and these studies have allowed optimization of the production method. The in vitro and in vivo biological properties have been investigated with a range of filler content and have shown that the presence of sufficient bioactive filler leads to a bioactive composite. Finally, the material has been applied clinically, initially in the orbital floor and later in the middle ear. From this initial combination of HA in PE other bioactive ceramic polymer composites have been developed.
School of Engineering, University of Glasgow, Glasgow, UK. firstname.lastname@example.org
This article was published in the following journal.
Name: Journal of the Royal Society, Interface / the Royal Society
- PubMed Source: http://www.ncbi.nlm.nih.gov/pubmed/20591846
- DOI: http://dx.doi.org/10.1098/rsif.2010.0229.focus
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Medical and Biotech [MESH] Definitions
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Agents that inhibit BONE RESORPTION and/or favor BONE MINERALIZATION and BONE REGENERATION. They are used to heal BONE FRACTURES and to treat METABOLIC BONE DISEASES.
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