Evolutionary history of regulatory variation in human populations.
Summary of "Evolutionary history of regulatory variation in human populations."
Genetic variation in the regulation of gene expression is likely to be a major contributor to phenotypic variation in humans, and it also constitutes an important target of recent natural selection in human populations and plays a major role in morphological evolution. The increasing amount of data of genome and transcriptome variation is now leading to a better annotation of regulatory elements and a growing understanding of how the evolution of gene regulation has shaped human diversity. In this review, we discuss the evolutionary history of the variation in the expression of protein-coding genes in humans. We outline the current methodology for mapping regulatory variants and their distribution in human populations. General mechanisms of regulatory evolution are discussed with a special emphasis on different selective processes targeting gene regulation in humans.
Affiliation
Journal Details
This article was published in the following journal.
Name: Human molecular genetics
ISSN: 1460-2083
Pages: R197-203
Links
- PubMed Source: http://www.ncbi.nlm.nih.gov/pubmed/20876617
- DOI: http://dx.doi.org/10.1093/hmg/ddq406
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Human Body
The human being as a non-anatomical and non-zoological entity. The emphasis is on the philosophical or artistic treatment of the human being, and includes lay and social attitudes toward the body in history. (From J. Cassedy, NLM History of Medicine Division)
Sociobiology
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