Early detection of prostate cancer : Is serum PSA testing alone sufficient?
Summary of "Early detection of prostate cancer : Is serum PSA testing alone sufficient?"
The euphoria over PSA as an optimal marker for prostate cancer is gone. Measuring PSA levels has several deficiencies in detecting prostate cancer. First results of the randomized studies ERSPC and PLCO were not able to conclusively prove the value of PSA-based screening. Many attempts have been made to optimize early detection of prostate cancer like using modern imaging techniques or new biomarkers. This review deals with PSA isoforms und emerging biomarkers for the diagnosis of prostate cancer. Despite the inadequacies of PSA it is still the most important marker for the early detection of prostate cancer. Modern biomarkers with the ability to reliably predict aggressive prostate cancer are still missing.
Affiliation
Klinik und Poliklinik für Urologie, Uroonkologie und Kinderurologie, Universitätsklinik Essen, Essen, Deutschland, christof.boergermann@krankenhaus-dueren.de.
Journal Details
This article was published in the following journal.
Name: Der Urologe. Ausg. A
ISSN: 1433-0563
Pages:
Links
- PubMed Source: http://www.ncbi.nlm.nih.gov/pubmed/20959954
- DOI: http://dx.doi.org/10.1007/s00120-010-2394-5
Medical and Biotech [MESH] Definitions
Early Detection Of Cancer
Methods to identify and characterize cancer in the early stages of disease and predict tumor behavior.
Prostate-specific Antigen
A glycoprotein that is a kallikrein-like serine proteinase and an esterase, produced by epithelial cells of both normal and malignant prostate tissue. It is an important marker for the diagnosis of prostate cancer.
Genetic Testing
Detection of or testing for certain ALLELES, mutations, genotypes, or karyotypes that are associated with genetic traits, heritable diseases, or with a predisposition to a disease, or that may lead to the disease in descendants. It includes prenatal genetic testing.
Indigotindisulfonate Sodium
An indolesulfonic acid that is used as a dye in renal function testing and as a reagent for the detection of nitrates and chlorates and in the testing of milk.
Seroepidemiologic Studies
EPIDEMIOLOGIC STUDIES based on the detection through serological testing of characteristic change in the serum level of specific ANTIBODIES. Latent subclinical infections and carrier states can thus be detected in addition to clinically overt cases.
PubMed Articles
Background:The accuracy of prostate-specific antigen (PSA) testing in prostate cancer detection is constrained by low sensitivity and specificity. Dysregulated expression of minichromosome maintenance...
Urinary biomarkers for prostate cancer: a review.
Although the routine use of serum prostate-specific antigen (PSA) testing has undoubtedly increased prostate cancer (PCa) detection, one of its main drawbacks is its lack of specificity. As a conseque...
Reduced Risk of Prostate Cancer in U.S. Men with AIDS.
BACKGROUND: Previous studies describe decreased prostate cancer risk in HIV-infected men. In the U.S., prostate-specific antigen (PSA) screening is common and increases detection of prostate cancer. W...
To screen or not to screen: ongoing debate in the early detection of prostate cancer.
Debate about the use of prostate-specific antigen (PSA) tests to screen prostate cancer in men is ongoing. Prostate cancer is the most common cancer after skin cancer in men and the second most deadly...
Balancing the harms and benefits of early detection of prostate cancer.
BACKGROUND:: The benefits of prostate cancer screening on an individual level remain unevaluated. METHODS:: Between 1993 and 1999, a total of 43,987 men, aged 55-74 years, were included in the interve...
Clinical Trials
Early Detection of Prostate Cancer by FACS
Early detection of prostrate cancer and development of metastases. The research will attempt to match the SCM test (structuredness of the cytoplasmic matrix) in lymphocytes as an early can...
Molecular Urine Tests for Prostate Cancer
Prostate cancer is the second leading cause of cancer related deaths among men in the United States.1 Although still controversial, there is growing evidence that early detection will redu...
Osteoporosis Among Men Treated With Androgen Deprivation for Prostate Cancer
The purpose of this study is - to determine the rate of osteoporosis among patients with advanced prostate cancer. - to propose an algorithm for early detection of patients with ad...
UCI 03-72 Prostate Cancer Detection by Serum Proteomic Profiling
: Researchers would like to see if a new test called SELDI (Surface Enhanced Laser Desorption Ionization) analysis can predict biopsy results better than PSA tests.
Vitamin D3 and Early-Stage Prostate Cancer in Active Surveillance
This clinical trial is aimed at measuring the effect of vitamin D3 supplementation on serum prostate-specific antigen (PSA) levels in patients diagnosed with early stage, low-grade, low-ri...
