Early detection of prostate cancer : Is serum PSA testing alone sufficient?
Summary of "Early detection of prostate cancer : Is serum PSA testing alone sufficient?"
The euphoria over PSA as an optimal marker for prostate cancer is gone. Measuring PSA levels has several deficiencies in detecting prostate cancer. First results of the randomized studies ERSPC and PLCO were not able to conclusively prove the value of PSA-based screening. Many attempts have been made to optimize early detection of prostate cancer like using modern imaging techniques or new biomarkers. This review deals with PSA isoforms und emerging biomarkers for the diagnosis of prostate cancer. Despite the inadequacies of PSA it is still the most important marker for the early detection of prostate cancer. Modern biomarkers with the ability to reliably predict aggressive prostate cancer are still missing.
Klinik und Poliklinik für Urologie, Uroonkologie und Kinderurologie, Universitätsklinik Essen, Essen, Deutschland, email@example.com.
This article was published in the following journal.
Name: Der Urologe. Ausg. A
- PubMed Source: http://www.ncbi.nlm.nih.gov/pubmed/20959954
- DOI: http://dx.doi.org/10.1007/s00120-010-2394-5
Medical and Biotech [MESH] Definitions
Early Detection Of Cancer
Methods to identify and characterize cancer in the early stages of disease and predict tumor behavior.
A glycoprotein that is a kallikrein-like serine proteinase and an esterase, produced by epithelial cells of both normal and malignant prostate tissue. It is an important marker for the diagnosis of prostate cancer.
Detection of or testing for certain ALLELES, mutations, genotypes, or karyotypes that are associated with genetic traits, heritable diseases, or with a predisposition to a disease, or that may lead to the disease in descendants. It includes prenatal genetic testing.
An indolesulfonic acid that is used as a dye in renal function testing and as a reagent for the detection of nitrates and chlorates and in the testing of milk.
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