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Well-differentiated papillary mesothelioma of the peritoneum is a rare subtype of epitheloid mesothelioma, which is usually seen in young women. Well-differentiated papillary mesothelioma of the peritoneum is generally considered of low malignant potential, however the long-term nature of the tumor remains poorly defined. CASE
We describe the long-term follow-up of a 60-year-old woman of West African descent who has survived 24 years with well-differentiated papillary mesothelioma of the peritoneum after receiving extensive local and systemic adjuvant chemotherapy. Her clinical course has included three exploratory laparotomies with intraperitoneal and intravenous chemotherapy over two decades. Her course was complicated by anthracycline-induced cardiomyopathy, for which she underwent an orthotopic heart transplant. Our patient is alive with stable radiological evidence of peritoneal disease, and continues to suffer from chronic abdominal pain.
No consensus exists regarding optimal treatment strategies for well-differentiated papillary mesothelioma of the peritoneum. However, given the low malignant potential of the tumor, careful consideration should be made before proceeding with aggressive interventions. Further, long-term follow-up reports are required to fully characterize this tumor.
This article was published in the following journal.
Name: Journal of medical case reports
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A malignant cystic or semicystic neoplasm. It often occurs in the ovary and usually bilaterally. The external surface is usually covered with papillary excrescences. Microscopically, the papillary patterns are predominantly epithelial overgrowths with differentiated and undifferentiated papillary serous cystadenocarcinoma cells. Psammoma bodies may be present. The tumor generally adheres to surrounding structures and produces ascites. (From Hughes, Obstetric-Gynecologic Terminology, 1972, p185)
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A persistent increase in synaptic efficacy, usually induced by appropriate activation of the same synapses. The phenomenological properties of long-term potentiation suggest that it may be a cellular mechanism of learning and memory.
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