Chronic morphine treatment decreases acoustic startle response and prepulse inhibition in rats.
Summary of "Chronic morphine treatment decreases acoustic startle response and prepulse inhibition in rats."
The reward-related effects of addictive drugs primarily act via the dopamine system, which also plays an important role in sensorimotor gating. The mesolimbic dopamine system is the common pathway of drug addiction and sensorimotor gating. However, the way in which addictive drugs affect sensorimotor gating is currently unclear. In previous studies, we examined the effects of morphine treatment on sensory gating in the hippocampus. The present study investigated the effects of morphine on sensorimotor gating in rats during chronic morphine treatment and withdrawal. Rats were examined during treatment with morphine for 10 successive days, followed by a withdrawal period. Acoustic startle responses to a single startle stimulus (115 dB SPL) and prepulse inhibition responses were recorded. The results showed that acoustic startle responses were attenuated during morphine treatment, but not during withdrawal. PPI was impaired in the last 2 morphine treatment days, but returned to a normal level during withdrawal.
Affiliation
State Key Laboratory of Brain and Cognitive Science, Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming, 650223, China.
Journal Details
This article was published in the following journal.
Name: Science China. Life sciences
ISSN: 1869-1889
Pages: 1356-60
Links
- PubMed Source: http://www.ncbi.nlm.nih.gov/pubmed/21046328
- DOI: http://dx.doi.org/10.1007/s11427-010-4077-2
Medical and Biotech [MESH] Definitions
Startle Reaction
A complex involuntary response to an unexpected strong stimulus usually auditory in nature.
Rhinometry, Acoustic
Diagnostic measurement of the nose and its cavity through acoustic reflections. Used to measure nasal anatomical landmarks, nasal septal deviation, and nasal airway changes in response to allergen provocation tests (NASAL PROVOCATION TESTS).
Acoustic Stimulation
Use of sound to elicit a response in the nervous system.
Reflex, Acoustic
Intra-aural contraction of tensor tympani and stapedius in response to sound.
Morphine
The principal alkaloid in opium and the prototype opiate analgesic and narcotic. Morphine has widespread effects in the central nervous system and on smooth muscle.
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