Myocardial perfusion imaging using technetium-99m sestamibi in asymptomatic diabetic patients.
Summary of "Myocardial perfusion imaging using technetium-99m sestamibi in asymptomatic diabetic patients."
Myocardial perfusion single-photon emission computed tomography (SPECT) has been extensively applied in the clinical assessment of patients with diabetes mellitus. The aim of the present study was to evaluate stress technetium-99m sestamibi SPECT MPI perfusion in silent myocardial ischemia and its association with some clinical and laboratory parameters in an asymptomatic diabetic population. Patients, material, methods: 83 subjects (age: 57.1±6.9 years) with at least five years history of type 2 diabetes, and no suspected or documented coronary artery disease (CAD) accomplished myocardial perfusion imaging; angiography was also performed in patients with abnormal MPI. Results: MPI results showed that 58 patients had normal myocardial perfusion, while 25 patients showed perfusion defects (23 reversible and 2 fixed) on MPI. 12 out of the 25 (48%) with abnormal MPI findings represented abnormal angiography. We observed that pretest likelihood of CAD (odds ratio 2.32; 95%-
CI:
1.05-5.13; p = 0.038) and higher HbA1c level (odds ratio 1.70; 95%-CI, 1.07-2.71; p = 0.02) were independently associated with abnormal MPI. Conclusion: Occult CAD was present on MPI in 1/3 patients with DM without abnormal electrocardiographic findings or evidence of peripheral arterial disease.
Affiliation
Majid Assadi, MDBushehr Research Center for Nuclear Medicine The Persian Gulf Biomedical Sciences InstituteBoostan 19 Alley, Imam Khomeini Street, Bushehr, Iran, Tel. +98/771/258 01 69, Fax +98/771/2541828, E-mail: assadipoya@yahoo.com, asadi@bpums.ac.ir.
Journal Details
This article was published in the following journal.
Name: Nuklearmedizin. Nuclear medicine
ISSN: 0029-5566
Pages:
Links
- PubMed Source: http://www.ncbi.nlm.nih.gov/pubmed/21052610
- DOI: http://dx.doi.org/10.3413/nukmed-0318-10-05
Medical and Biotech [MESH] Definitions
Myocardial Perfusion Imaging
The creation and display of functional images showing where the blood is flowing into the MYOCARDIUM by following over time the distribution of tracers injected into the blood stream.
Technetium Tc 99m Sestamibi
A technetium imaging agent used to reveal blood-starved cardiac tissue during a heart attack.
Diabetic Cardiomyopathies
Diabetes complications in which VENTRICULAR REMODELING in the absence of CORONARY ATHEROSCLEROSIS and hypertension results in cardiac dysfunctions, typically LEFT VENTRICULAR DYSFUNCTION. The changes also result in myocardial hypertrophy, myocardial necrosis and fibrosis, and collagen deposition due to impaired glucose tolerance.
Molecular Imaging
The use of molecularly targeted imaging probes to localize and/or monitor biochemical and cellular processes via various imaging modalities that include RADIONUCLIDE IMAGING; ULTRASONOGRAPHY; MAGNETIC RESONANCE IMAGING; fluorescence imaging; and MICROSCOPY.
Technetium Tc 99m Exametazime
A gamma-emitting radionuclide imaging agent used in the evaluation of regional cerebral blood flow and in non-invasive dynamic biodistribution studies and myocardial imaging. It has also been used to label leukocytes in the investigation of inflammatory bowel diseases.
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