Update on Preparation for Colonoscopy.
Summary of "Update on Preparation for Colonoscopy."
Colonoscopy requires adequate bowel cleansing to be safe and effective. Current options for preparation include dietary restrictions plus cathartics and purgatives, large-volume gut lavage solutions, and sodium phosphate preparations. Gut lavage with or without a stimulant laxative is safe and effective, and traditionally is taken the evening before the procedure. Sodium phosphate formulations also provide effective cleansing, but fluid and electrolyte disturbances can occur. Recent advances include split administration of gut lavage solutions-ingesting only half of the solution the evening prior to, and the rest the morning of, the procedure. Split administration can yield adequate preparations in inpatients, traditionally a difficult group for proper cleansing. A new oral sulfate solution, when commercially available, should provide safe, effective cleaning with a lower ingested volume. This review discusses the current clinical experience of available preparation options and the efforts to make preparation for colonoscopy more tolerable.
Affiliation
Division of Gastroenterology, College of Medicine, University of South Alabama, Mobile, AL, USA, slandreneau@usouthal.edu.
Journal Details
This article was published in the following journal.
Name: Current gastroenterology reports
ISSN: 1534-312X
Pages:
Links
- PubMed Source: http://www.ncbi.nlm.nih.gov/pubmed/20640945
- DOI: http://dx.doi.org/10.1007/s11894-010-0121-4
Medical and Biotech [MESH] Definitions
Colonoscopy
Endoscopic examination, therapy or surgery of the luminal surface of the colon.
Cathartics
Agents that are used to evacuate the bowels to eliminate ingested NOXAE or to prepare for COLONOSCOPY.
Oral Medicine
A branch of dentistry dealing with diseases of the oral and paraoral structures and the oral management of systemic diseases. (Hall, What is Oral Medicine, Anyway? Clinical Update: National Naval Dental Center, March 1991, p7-8)
Colitis, Microscopic
A condition characterized by chronic watery DIARRHEA of unknown origin, a normal COLONOSCOPY but abnormal histopathology on BIOPSY. This syndrome was first described in 1980 by Read and associates. Subtypes include COLLAGENOUS COLITIS and LYMPHOCYTIC COLITIS. Both have similar clinical symptoms and are distinguishable only by histology.
Colitis, Collagenous
A subtype of MICROSCOPIC COLITIS, characterized by chronic watery DIARRHEA of unknown origin, a normal COLONOSCOPY but abnormal histopathology on BIOPSY. Microscopic examination of biopsy samples taken from the COLON show larger-than-normal band of subepithelial COLLAGEN.
PubMed Articles
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A shorter preparation to procedure interval for colonoscopy improves quality of bowel cleansing.
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Should barium enema be the next step following an incomplete colonoscopy?
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Clinical Trials
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Efficacy Study of Bowel Preparation Before Colonoscopy
The purpose of this study is to determine the efficacious dose range when used as a bowel preparation before colonoscopy.
BLI-800-301: BLI-800 vs an Active Control Bowel Preparation in Adult Subjects Undergoing Colonoscopy
This is a randomized, parallel, multi-center, single-blind study, comparing BLI-800 to an FDA approved bowel preparation in adult subjects undergoing colonoscopy.
BLI-800-302: BLI-800 vs an Active Control Bowel Preparation in Adult Subjects Undergoing Colonoscopy
This is a randomized, parallel, multi-center, single-blind study, comparing BLI-800 to an FDA approved bowel preparation in adult subjects undergoing colonoscopy.