Vitamin D status and metabolic syndrome in Asian Indians.
Summary of "Vitamin D status and metabolic syndrome in Asian Indians."
In this study, we aimed to estimate serum 25-hydroxy vitamin D (25-OH-D) in Asian Indians and test for association between 25-OH-D levels, insulin resistance (IR) and metabolic syndrome (MS). Serum 25-OH-D was measured in a cross-sectional sample of 441 Indians, aged 39.7±12.8 years (237 men and 204 women) with 27.9% prevalence of MS. Vitamin D insufficiency (12.5 to <50 nmol l(-1)) and hypovitaminosis D (50 to <100 nmol l(-1)) were present in 65.6 and 31.1% of participants, respectively. The 25-OH-D levels did not differ significantly between sexes (P=0.057). Multivariate regression analysis indicated a positive relationship between 25-OH-D and β-cell function (homeostasis model assessment (HOMA)-B; β=0.245, P=0.006), whereas regression coefficients for fasting glucose (β=0.262, P=0.794), insulin (β=-0.140, P=0.889) and HOMA-IR (β=-0.119, P=0.172) were insignificant. Sex-stratified analysis showed no linear trend for increasing quintiles of 25-OH-D with prevalence of MS or its components (P>0.05). Although highly prevalent, vitamin D insufficient status was not associated with MS or IR in Asian Indians of either sex.International Journal of Obesity advance online publication, 9 November 2010; doi:10.1038/ijo.2010.232.
Affiliation
Department of Neurochemistry, National Institute of Mental Health and Neuro Sciences, Bangalore, India.
Journal Details
This article was published in the following journal.
Name: International journal of obesity (2005)
ISSN: 1476-5497
Pages:
Links
- PubMed Source: http://www.ncbi.nlm.nih.gov/pubmed/21060309
- DOI: http://dx.doi.org/10.1038/ijo.2010.232
Medical and Biotech [MESH] Definitions
Inositol
An isomer of glucose that has traditionally been considered to be a B vitamin although it has an uncertain status as a vitamin and a deficiency syndrome has not been identified in man. (From Martindale, The Extra Pharmacopoeia, 30th ed, p1379) Inositol phospholipids are important in signal transduction.
Metabolic Syndrome X
A cluster of metabolic risk factors for CARDIOVASCULAR DISEASES and TYPE 2 DIABETES MELLITUS. The major components of metabolic syndrome X include excess ABDOMINAL FAT; atherogenic DYSLIPIDEMIA; HYPERTENSION; HYPERGLYCEMIA; INSULIN RESISTANCE; a proinflammatory state; and a prothrombotic (THROMBOSIS) state. (from AHA/NHLBI/ADA Conference Proceedings, Circulation 2004; 109:551-556)
Vitamin K
A lipid cofactor that is required for normal blood clotting. Several forms of vitamin K have been identified: VITAMIN K 1 (phytomenadione) derived from plants, VITAMIN K 2 (menaquinone) from bacteria, and synthetic naphthoquinone provitamins, VITAMIN K 3 (menadione). Vitamin K 3 provitamins, after being alkylated in vivo, exhibit the antifibrinolytic activity of vitamin K. Green leafy vegetables, liver, cheese, butter, and egg yolk are good sources of vitamin K.
Status Epilepticus
A prolonged seizure or seizures repeated frequently enough to prevent recovery between episodes occurring over a period of 20-30 minutes. The most common subtype is generalized tonic-clonic status epilepticus, a potentially fatal condition associated with neuronal injury and respiratory and metabolic dysfunction. Nonconvulsive forms include petit mal status and complex partial status, which may manifest as behavioral disturbances. Simple partial status epilepticus consists of persistent motor, sensory, or autonomic seizures that do not impair cognition (see also EPILEPSIA PARTIALIS CONTINUA). Subclinical status epilepticus generally refers to seizures occurring in an unresponsive or comatose individual in the absence of overt signs of seizure activity. (From N Engl J Med 1998 Apr 2;338(14):970-6; Neurologia 1997 Dec;12 Suppl 6:25-30)
Indians, Central American
Individual members of Central American ethnic groups with ancient historic ancestral origins in Asia. Mexican Indians are not included.
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