Synthesis and molecular modelling studies of prenylated pyrazolines as MAO-B inhibitors.
Summary of "Synthesis and molecular modelling studies of prenylated pyrazolines as MAO-B inhibitors."
A series of N-substituted-3-[(2'-hydroxy-4'-prenyloxy)-phenyl]-5-phenyl-4,5-dihydro-(1H)-pyrazolines were synthesized and tested on human monoamine oxidase-A and -B isoforms. Structure-activity relationships and molecular modelling showed that some substitutions, such as benzyloxy or chlorine atom, improve the best interaction with active site of hMAO-B.
Affiliation
Dipartimento di Chimica e Tecnologie del Farmaco, Università di Roma La Sapienza P.le Aldo Moro, 5, 00185 Rome, Italy. rossella.fioravanti@uniroma1.it
Journal Details
This article was published in the following journal.
Name: Bioorganic & medicinal chemistry letters
ISSN: 1464-3405
Pages: 6479-82
Links
- PubMed Source: http://www.ncbi.nlm.nih.gov/pubmed/20934874
- DOI: http://dx.doi.org/10.1016/j.bmcl.2010.09.061
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