Polymorphisms in the MTHRF, VDR, MMP-9 and IL-beta Genes and the Risk of Premature Rupture of Membranes.
Summary of "Polymorphisms in the MTHRF, VDR, MMP-9 and IL-beta Genes and the Risk of Premature Rupture of Membranes."
Background: Premature rupture of membranes (PROM) occurs 2.5-3 times more often in premature births than in births that are full term, is accompanied by many complications for both the mother and fetus and can cause serious adverse consequences. Little is known about the genetic susceptibility of PROM. Objective: The purpose of this study was to evaluate the association between several genotypes and PROM in a high-risk hospital-based population. Methods: The cases were 206 pregnant women who had PROM in labor, and the controls were 287 pregnant women who did not have PROM in labor. All subjects were selected between July 2006 and July 2007 from the Maternal and Child Health Hospital in Jinan City. We genotyped the following genes: the MTHFR C677T, MMP-9 C1562T, VDR C352T and IL-1beta C3593T genotypes. The associations between the genotypes and risk of PROM were analyzed. Results: The CC genotype at MTHFR C677T, combined with bacterial vaginosis, was associated with a significantly increased risk of PROM (odds ratio,
OR:
3.55; 95% confidence interval,
CI:
1.05-12.02). Compared to those in the stratum of 40 or more weeks of gestation, those in the stratum of 37 or less weeks of gestation had an increased risk of PROM (
OR:
5.11, 95%
CI:
2.0-13.05 for the TT/TC genotype of MTHFR C677T;
OR:
5.31, 95%
CI:
1.07-26.44 for the TC/TT genotype of MMP-9 C1562T, and
OR:
6.08, 95%
CI:
1.39-26.60 for the TT genotype of VDR C352T). Conclusion: The results indicated that an interaction exists between genetic and environmental factors that are related to the occurrence of PROM.
Affiliation
Shandong Center for Disease Control and Prevention, Jinan, China.
Journal Details
This article was published in the following journal.
Name: Gynecologic and obstetric investigation
ISSN: 1423-002X
Pages: 206-214
Links
- PubMed Source: http://www.ncbi.nlm.nih.gov/pubmed/20639647
- DOI: http://dx.doi.org/10.1159/000318867
Medical and Biotech [MESH] Definitions
Fetal Membranes, Premature Rupture
Spontaneous tearing of the membranes surrounding the FETUS any time before the onset of OBSTETRIC LABOR. Preterm PROM is membrane rupture before 37 weeks of GESTATION.
Genes, T-cell Receptor Beta
DNA sequences encoding the beta chain of the T-cell receptor. The genomic organization of the TcR beta genes is essentially the same in all species and is similar to the organization of Ig genes.
Lac Operon
The genetic unit consisting of three structural genes, an operator and a regulatory gene. The regulatory gene controls the synthesis of the three structural genes: BETA-GALACTOSIDASE and beta-galactoside permease (involved with the metabolism of lactose), and beta-thiogalactoside acetyltransferase.
Behavioral Risk Factor Surveillance System
Telephone surveys are conducted to monitor prevalence of the major behavioral risks among adults associated with premature MORBIDITY and MORTALITY. The data collected is in regard to actual behaviors, rather than on attitudes or knowledge. The Centers for Disease Control and Prevention (CDC) established the Behavioral Risk Factor Surveillance System (BRFSS) in 1984.
Ventricular Premature Complexes
A type of cardiac arrhythmia with premature contractions of the HEART VENTRICLES. It is characterized by the premature QRS complex on ECG that is of abnormal shape and great duration (generally >129 msec). It is the most common form of all cardiac arrhythmias. Premature ventricular complexes have no clinical significance except in concurrence with heart diseases.
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