Impact of Acid Suppression on Upper Gastrointestinal pH and Motility.

20:42 EST 21st November 2014 | BioPortfolio

Summary of "Impact of Acid Suppression on Upper Gastrointestinal pH and Motility."


BACKGROUND:
Proton pump inhibitors (PPIs), widely prescribed to patients with upper gastrointestinal symptoms, alter intragastric pH, and may affect upper gastrointestinal transit and motility parameters in addition to affecting the ability to determine Wireless Motility Capsule (WMC) gastric emptying time.
AIM:
To assess PPI effect on motility parameters of the upper gastrointestinal tract and to determine if PPIs confound ability of WMC to measure gastric emptying time.
METHODS:
Twenty healthy subjects were treated with esomeprazole 40 mg bid for 1 week. Another 50 healthy subjects underwent evaluation in absence of PPIs. All subjects underwent WMC test after meal ingestion. After a rapid, sustained luminal pH rise ≥ 0.5 pH units, marking potential gastric emptying time of WMC, an abdominal X-ray (KUB) was taken for gastric emptying time confirmation. Mean pH, pressure and transit time were compared between PPI-treated and untreated groups.
RESULTS:
There was no difference in gastric emptying time, small bowel transit time (SBTT), or pressure profiles between the groups. The pH in all cases rose ≥ 0.5 pH units. Distal small bowel pH was significantly lower in subjects on PPIs. Gastric emptying time was identified in all subjects treated with PPIs. Pressure and slope criteria were developed to confirm the time of emptying.
CONCLUSION:
PPI therapy does not have a significant impact on upper gastrointestinal transit and motility but it does decrease distal small bowel pH. The medication reduced the magnitude of pH change at gastric emptying time but using additional criteria based on slope and contraction frequency, WMC was able to measure gastric emptying time in all patients treated with PPIs.

Affiliation

Massachusetts General Hospital, 55 Fruit St. GRJ 274, Boston, MA, 02114, USA, wmichalek@partners.org.

Journal Details

This article was published in the following journal.

Name: Digestive diseases and sciences
ISSN: 1573-2568
Pages:

Links

PubMed Articles [18773 Associated PubMed Articles listed on BioPortfolio]

Intra-gastric triacetin alters upper gastrointestinal motility in conscious dogs.

To examine the effect of intra-gastric triacetin on both upper gastrointestinal motility and proximal gastric tone in conscious dogs.

Gastrointestinal motility disorders in children.

The most common and challenging gastrointestinal motility disorders in children include gastroesophageal reflux disease (GERD), esophageal achalasia, gastroparesis, chronic intestinal pseudo-obstructi...

Clinical Utility of Wireless Motility Capsule in Patients with Suspected Multiregional Gastrointestinal Dysmotility.

Patients with gastrointestinal (GI) dysmotility often experience overlapping upper and lower GI symptoms suggestive of multiregional involvement. Wireless motility capsule (WMC) provides a full GI tra...

Reduced hemoglobin and increased C-reactive protein are associated with upper gastrointestinal bleeding.

To investigate the early upper gastrointestinal endoscopy (endoscopy) significantly reduces mortality resulting from upper gastrointestinal (GI) bleeding.

Gastric Acid Supression and Community Acquired Pneumonia: A Retrospective Analysis in an Inner City Community Hospital.

Respiratory InfectionsSESSION TYPE: Original Investigation SlidePRESENTED ON: Tuesday, October 28, 2014 at 11:00 AM - 12:15 PMPURPOSE: Gastrointestinal symptoms are very common in the general populati...

Clinical Trials [3439 Associated Clinical Trials listed on BioPortfolio]

MSG and Gastrointestinal Motility

The purpose of this study is to clarify the physiological function of sodium glutamate by measuring its effect on upper GI motility (esophageal manometry, impedance and gastric emptying).

Evaluation of Gastrointestinal Motility With SmartPill

The purpose of this study is to evaluate the clinical usefulness of a capsule (SmartPill~) measuring pH, pressure and temperature from within the entire GI tract to determine gastric empt...

Survey Examining the Frequency and Severity of Acid Related Symptoms While Taking Nexium

This study will assess the effectiveness of Nexium at alleviating upper GI symptoms in subjects and evaluate with which treatment regimen and on which indications acid suppression with iso...

Effect of Tranexamic Acid in Upper Gastrointestinal Bleeding

The investigators hypothesize that addition of Tranexamic acid, an antifibrinolytic agent, to conventional therapy will lead to an improved outcome characterized by lower transfusion requi...

Use of an Ambulatory Capsule to Characterize Gastrointestinal Pressure Patterns in Children

This study will test a new medical device called the SmartPill GI Monitoring System, which is now used to diagnose gastric motility disorders in adults, in children. The study will compare...

Medical and Biotech [MESH] Definitions

Drugs used for their effects on the gastrointestinal system, as to control gastric acidity, regulate gastrointestinal motility and water flow, and improve digestion.

The motor activity of the GASTROINTESTINAL TRACT.

A drug that exerts an inhibitory effect on gastric secretion and reduces gastrointestinal motility. It is used clinically in the drug therapy of gastrointestinal ulcers.

A biochemical messenger and regulator, synthesized from the essential amino acid L-TRYPTOPHAN. In humans it is found primarily in the central nervous system, gastrointestinal tract, and blood platelets. Serotonin mediates several important physiological functions including neurotransmission, gastrointestinal motility, hemostasis, and cardiovascular integrity. Multiple receptor families (RECEPTORS, SEROTONIN) explain the broad physiological actions and distribution of this biochemical mediator.

The segment of GASTROINTESTINAL TRACT that includes the ESOPHAGUS; the STOMACH; and the DUODENUM.

Search BioPortfolio:
Loading
Advertisement

Relevant Topics

Radiology
Latest News Clinical Trials Research Drugs Reports Corporate
Radiology is the branch of medicine that studies imaging of the body; X-ray (basic, angiography, barium swallows), ultrasound, MRI, CT and PET. These imaging techniques can be used to diagnose, but also to treat a range of conditions, by allowing visuali...

Pharmacy
Latest News Clinical Trials Research Drugs Reports Corporate
Pharmacy is the science and technique of preparing as well as dispensing drugs and medicines. It is a health profession that links health sciences with chemical sciences and aims to ensure the safe and effective use of pharmaceutical drugs. The scope of...

Advertisement