Role of uterine artery Doppler velocimetry indices and plasma adrenomedullin level in women with unexplained recurrent pregnancy loss.

06:00 EST 19th November 2010 | BioPortfolio

Summary of "Role of uterine artery Doppler velocimetry indices and plasma adrenomedullin level in women with unexplained recurrent pregnancy loss."

Aim:  To evaluate uterine artery Doppler flow resistance and plasma adrenomedullin levels in women with unexplained recurrent pregnancy loss (RPL) compared to controls. Material & Methods:  Eighty-three women, who attend the department of Obstetrics and Gynecology, Benha University, Egypt, participated in this study (RPL group: n = 40, and control group: n = 43). Uterine artery Doppler and plasma adrenomedullin (AM) (pg/mL) levels were measured for all women in the mid-luteal phase of a non-pregnant cycle. Results:  Both uterine artery pulsatility index (PI) and AM levels were significantly higher in RPL group compared to controls (2.71 ± 0.259 vs 2.06 ± 0.194 for PI and 287.5 ± 80.4 pg/mL vs 156.1 ± 39.8 pg/mL for AM, P < 0.01). Uterine artery PI had a significant positive correlation with plasma AM levels both in the RPL group (r = 0.645, P < 0.001) and in the control group (r = 0.384, P = 0.011). Number of previous miscarriages in RPL group was significantly correlated with both uterine artery PI (r = 0.838, P = 0.015) and plasma AM levels (r = 0.509, P = 0.001). Conclusions:  Uterine artery PI may be useful in identifying women with unexplained RPL who have impaired uterine circulation. Plasma AM may serve as a biochemical marker for RPL caused by impaired uterine perfusion.


Departments of Obstetrics and Gynecology Clinical and Chemical Pathology, Benha Faculty of Medicine, Benha University, Benha, Egypt.

Journal Details

This article was published in the following journal.

Name: The journal of obstetrics and gynaecology research
ISSN: 1341-8076


DeepDyve research library

PubMed Articles [17256 Associated PubMed Articles listed on BioPortfolio]

Diagnosis of Placenta Accreta by Uterine Artery Doppler Velocimetry in Patients With Placenta Previa.

To evaluate the potential value of uterine artery Doppler velocimetry in diagnosing placenta accreta.

Associations between first-trimester uterine artery Doppler velocimetry indices and adverse perinatal outcomes in women conceiving via in vitro fertilization.

To explore if first-trimester uterine artery Doppler velocimetric values might predict adverse perinatal outcomes in patients conceiving via in vitro fertilization (IVF).

Placental laterality and uterine blood flow at 20-40 weeks' gestation in low-risk pregnancies.

We sought to examine flow velocity waveforms of the uterine arteries with respect to placental location at 20-40 weeks' gestation. Blood flow (BF) volume, pulsatility index (PI), resistance index (RI)...

Doppler assessment of uterine blood flow in pre-eclampsia: a review.

Doppler ultrasonography plays an ever-increasing role in obstetric imaging. Although commonly purported to assess blood flow, most studies in this area report purely on velocimetric parameters, rather...

Can fetal pulmonary artery Doppler indices predict neonatal respiratory distress syndrome?

To study whether fetal main pulmonary artery (MPA) Doppler indices can predict the development of neonatal respiratory distress syndrome (RDS).

Clinical Trials [4727 Associated Clinical Trials listed on BioPortfolio]

The Association Between Uterine Artery Notch and First Trimester Bleeding

The purpose of the present study is to evaluate the occurrence of first trimester bleeding among patients with abnormal uterine artery Doppler. A prospective study is designed and two gro...

Uterine Artery Occlusion for Fibroid Related Bleeding

The primary objective of this study is to evaluate the safety and effectiveness of Doppler guided Uterine Artery Occlusion (D-UAO) as treatment for the reduction of fibroid-associated symp...

IUD Uterine Vascularization and Side Effects

The aim of this study was to evaluate the effect of the LNG-IUS and TCU 380A users on the sub-endometrial vascularization and the uterine artery blood flow using power Doppler analysis and...

The Role of Adrenomedullin on the Outcome of Severe Heart Failure: a Clinical Randomized Study

1. Study Hypothesis: - The decrease of plasma adrenomedullin (ADM) concentration by ultrafiltration and isovolumetric hemofiltration in patients with acute III and IV Cl...

Prediction of Preeclampsia & Other Obstetric Complications by Serum Homocysteine & Doppler

Second trimester homocysteine & uterine artery doppler will be assessed& the cases will be followed up till delivery for development of preeclampsia, IUGR(intra-uterine growth retardation)...

Medical and Biotech [MESH] Definitions

A branch arising from the internal iliac artery in females, that supplies blood to the uterus.

The use of embolizing agents to block the arterial blood supply to parts or all of the UTERUS. The procedures are done to control bleeding or to cause destruction of uterine tissues.

Ultrasonography applying the Doppler effect combined with real-time imaging. The real-time image is created by rapid movement of the ultrasound beam. A powerful advantage of this technique is the ability to estimate the velocity of flow from the Doppler shift frequency.

A 52-amino acid peptide with multi-functions. It was originally isolated from PHEOCHROMOCYTOMA and ADRENAL MEDULLA but is widely distributed throughout the body including lung and kidney tissues. Besides controlling fluid-electrolyte homeostasis, adrenomedullin is a potent vasodilator and can inhibit pituitary ACTH secretion.

Echocardiography applying the Doppler effect, with the superposition of flow information as colors on a gray scale in a real-time image.

Quick Search

DeepDyve research library

Relevant Topics

Blood is a specialized bodily fluid that delivers necessary substances to the body's cells (in animals) – such as nutrients and oxygen – and transports waste products away from those same cells.  In vertebrates, it is composed of blo...

Women's Health
Women's Health - key topics include breast cancer, pregnancy, menopause, stroke Follow and track Women's Health News on BioPortfolio: Women's Health News RSS Women'...

Obstetrics and gynaecology
Fertility Menopause Obstetrics & Gynaecology Osteoporosis Women's Health Obstetrics and gynaecology comprises the care of the pregnant woman, her unborn child and the management of diseases specific to women. Most consultant...

Searches Linking to this Article