Association between serum IGF-1 and diabetes mellitus among US adults.
Summary of "Association between serum IGF-1 and diabetes mellitus among US adults."
AbstractBackground: Serum insulin-like growth factor (IGF-1) may have a role in the maintenance of glucose homeostasis. We examined the association between serum IGF-1 and diabetes mellitus in a representative sample of US adults. Methods: Third National Health and Nutrition Examination Survey participants aged >/=18 years (n=5,511). Main outcome was the presence of diabetes mellitus (n = 387). Results: Lower serum IGF-1 levels were positively associated with diabetes mellitus after adjusting for age, sex, race/ethnicity, education, smoking, alcohol intake, body mass index, hypertension, glomerular filtration rate and serum cholesterol. Compared to quartile 4 of IGF-1 (referent), the odds ratio [OR] (95% confidence interval) of diabetes associated with quartile 1 was 2.16 (1.24-3.76); p-trend=0.002. However, the observed association between IGF-1 and diabetes was present only in those <65 years (OR=3.05; p-trend=0.006) and disappeared in those >/=65 years (OR=0.51; p-trend=0.18); p-interaction=0.0056. Conclusion: Low IGF-1 levels are associated with diabetes mellitus among young subjects.
Affiliation
1. Department of Community Medicine, West Virginia University School of Medicine, Morgantown, WV 26506.
Journal Details
This article was published in the following journal.
Name: Diabetes care
ISSN: 1935-5548
Pages:
Links
- PubMed Source: http://www.ncbi.nlm.nih.gov/pubmed/20639451
- DOI: http://dx.doi.org/10.2337/dc10-0770
Medical and Biotech [MESH] Definitions
Diabetes Mellitus, Type 2
A subclass of DIABETES MELLITUS that is not INSULIN-responsive or dependent (NIDDM). It is characterized initially by INSULIN RESISTANCE and HYPERINSULINEMIA; and eventually by GLUCOSE INTOLERANCE; HYPERGLYCEMIA; and overt diabetes. Type II diabetes mellitus is no longer considered a disease exclusively found in adults. Patients seldom develop KETOSIS but often exhibit OBESITY.
Diabetes Mellitus, Experimental
Diabetes mellitus induced experimentally by administration of various diabetogenic agents or by PANCREATECTOMY.
Polyuria
Urination of a large volume of urine with an increase in urinary frequency, commonly seen in diabetes (DIABETES MELLITUS; DIABETES INSIPIDUS).
Diabetes Mellitus, Type 1
A subtype of DIABETES MELLITUS that is characterized by INSULIN deficiency. It is manifested by the sudden onset of severe HYPERGLYCEMIA, rapid progression to DIABETIC KETOACIDOSIS, and DEATH unless treated with insulin. The disease may occur at any age, but is most common in childhood or adolescence.
Rats, Inbred Bb
A strain of Rattus norvegicus which is a model for spontaneous insulin-dependent diabetes mellitus (DIABETES MELLITUS, INSULIN-DEPENDENT).
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