Diffusion tensor imaging of the kidney at 3 Tesla: normative values and repeatability of measurements in healthy volunteers.

06:00 EST 26th November 2010 | BioPortfolio

Summary of "Diffusion tensor imaging of the kidney at 3 Tesla: normative values and repeatability of measurements in healthy volunteers."

To evaluate the feasibility of renal diffusion tensor imaging and determine the normative fractional anisotropy and apparent diffusion coefficient values at 3 Tesla MRI using parallel imaging and free breathing technique. MATERIALS AND
A total of 52 young healthy volunteers with no history of renal disease were included in the study. MRI examinations were performed with 3 Tesla MRI equipment, using six-channel phased array SENSE Torso coil. In all subjects, T2-weighted turbo spin echo and diffusion tensor imaging using single shot echo planar imaging sequences were obtained in the coronal plane with free breathing. Field of view, slice thickness and slice gap values were identical for both sequences for anatomic correlation during analysis of diffusion tensor imaging data. Parallel imaging method was used with a SENSE factor of 2. Diffusion tensor parameters of the cortex and medulla were determined and the intra- and inter-observer measurement variances were calculated.
The mean fractional anisotropy of the medulla was significantly higher than that of the cortex, whereas the mean apparent diffusion coefficient of the medulla was lower when compared with that of the cortex. According to the two-sided paired samples Student's t test, the intra- and inter-observer measurements correlated well.
This study shows the feasibility of renal diffusion tensor imaging and repeatibility of diffusion tensor parameter measurements in 3 Tesla MRI.


Department of Radiology, Yeditepe University School of Medicine, Istanbul, Turkey.

Journal Details

This article was published in the following journal.

Name: Diagnostic and interventional radiology (Ankara, Turkey)
ISSN: 1305-3612


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Medical and Biotech [MESH] Definitions

The use of diffusion ANISOTROPY data from diffusion magnetic resonance imaging results to construct images based on the direction of the faster diffusing molecules.

A diagnostic technique that incorporates the measurement of molecular diffusion (such as water or metabolites) for tissue assessment by MRI. The degree of molecular movement can be measured by changes of apparent diffusion coefficient (ADC) with time, as reflected by tissue microstructure. Diffusion MRI has been used to study BRAIN ISCHEMIA and tumor response to treatment.

The use of molecularly targeted imaging probes to localize and/or monitor biochemical and cellular processes via various imaging modalities that include RADIONUCLIDE IMAGING; ULTRASONOGRAPHY; MAGNETIC RESONANCE IMAGING; fluorescence imaging; and MICROSCOPY.

The complete summaries of the frequencies of the values or categories of a measurement made on a group of items, a population, or other collection of data. The distribution tells either how many or what proportion of the group was found to have each value (or each range of values) out of all the possible values that the quantitative measure can have.

The tendency of a gas or solute to pass from a point of higher pressure or concentration to a point of lower pressure or concentration and to distribute itself throughout the available space. Diffusion, especially FACILITATED DIFFUSION, is a major mechanism of BIOLOGICAL TRANSPORT.


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