Classification of adrenal cortical tumors: Promise of the 'molecular' approach.
Summary of "Classification of adrenal cortical tumors: Promise of the 'molecular' approach."
Surgical pathologists, using routine histological techniques and tumor morphology, have established the overall taxonomy of adrenal cortical tumors that dictates care of patients with these tumors. However, a novel molecular classification of these tumors would provide numerous benefits to clinicians and patients, including a more accurate classification of diagnostically intermediate tumors, separation of carcinomas into prognostically-relevant subgroups, and optimal selection of therapy. Recent advances towards a molecular classification of adrenal cortical tumors are presented and discussed.
Affiliation
University of Michigan Medical School, Department of Pathology, MSRB2, C570D, Ann Arbor, MI 48109, United States.
Journal Details
This article was published in the following journal.
Name: Best practice & research. Clinical endocrinology & metabolism
ISSN: 1532-1908
Pages: 887-92
Links
- PubMed Source: http://www.ncbi.nlm.nih.gov/pubmed/21115157
- DOI: http://dx.doi.org/10.1016/j.beem.2010.10.012
Medical and Biotech [MESH] Definitions
Pituitary-adrenal System
The interactions between the anterior pituitary and adrenal glands, in which corticotropin (ACTH) stimulates the adrenal cortex and adrenal cortical hormones suppress the production of corticotropin by the anterior pituitary.
Adrenal Rest Tumor
Neoplasm derived from displaced cells (rest cells) of the primordial ADRENAL GLANDS, generally in patients with CONGENITAL ADRENAL HYPERPLASIA. Adrenal rest tumors have been identified in TESTES; LIVER; and other tissues. They are dependent on ADRENOCORTICOTROPIN for growth and adrenal steroid secretion.
Adrenal Gland Neoplasms
Tumors or cancer of the ADRENAL GLANDS.
Steroid 21-hydroxylase
An adrenal microsomal cytochrome P450 enzyme that catalyzes the 21-hydroxylation of steroids in the presence of molecular oxygen and NADPH-FERRIHEMOPROTEIN REDUCTASE. This enzyme, encoded by CYP21 gene, converts progesterones to precursors of adrenal steroid hormones (CORTICOSTERONE; HYDROCORTISONE). Defects in CYP21 cause congenital adrenal hyperplasia (ADRENAL HYPERPLASIA, CONGENITAL).
Adrenal Cortex Neoplasms
Tumors or cancers of the ADRENAL CORTEX.
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