The stem cell "tunnel" effect.
Summary of "The stem cell "tunnel" effect."
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Center for Cell and Gene Therapy, Baylor College of Medicine, Houston, Texas, USA.
This article was published in the following journal.
Name: Molecular therapy : the journal of the American Society of Gene Therapy
- PubMed Source: http://www.ncbi.nlm.nih.gov/pubmed/21119690
- DOI: http://dx.doi.org/10.1038/mt.2010.245
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Medical and Biotech [MESH] Definitions
Methods of implanting a CELL NUCLEUS from a donor cell into an enucleated acceptor cell. Often the nucleus of a somatic cell is transferred into a recipient OVUM or stem cell (STEM CELLS) with the nucleus removed. This technology may provide means to generate autologous diploid pluripotent cell for therapeutic cloning, and a model for studying NUCLEAR REPROGRAMMING in embryonic stem cells. Nuclear transfer was first accomplished with frog eggs (RANA PIPIENS) and reported in 1952.
The release of stem cells from the bone marrow into the peripheral blood circulation for the purpose of leukapheresis, prior to stem cell transplantation. Hematopoietic growth factors or chemotherapeutic agents often are used to stimulate the mobilization.
The malignant stem cells of TERATOCARCINOMAS, which resemble pluripotent stem cells of the BLASTOCYST INNER CELL MASS. The EC cells can be grown in vitro, and experimentally induced to differentiate. They are used as a model system for studying early embryonic cell differentiation.
Experimentation on STEM CELLS and on the use of stem cells.
Transplantation of stem cells collected from the peripheral blood. It is a less invasive alternative to direct marrow harvesting of hematopoietic stem cells. Enrichment of stem cells in peripheral blood can be achieved by inducing mobilization of stem cells from the BONE MARROW.