Dicing up chromosomes: The unexpected role of Dicer in apoptosis.
Summary of "Dicing up chromosomes: The unexpected role of Dicer in apoptosis."
Comment on: Nakagawa A, et al. Science 2010; 328:327-34.
Affiliation
Journal Details
This article was published in the following journal.
Name: Cell cycle (Georgetown, Tex.)
ISSN: 1551-4005
Pages:
Links
- PubMed Source: http://www.ncbi.nlm.nih.gov/pubmed/21150320
- DOI: http://dx.doi.org/
Medical and Biotech [MESH] Definitions
Receptors, Tnf-related Apoptosis-inducing Ligand
Tumor necrosis factor receptor family members that are widely expressed and play a role in regulation of peripheral immune responses and APOPTOSIS. The receptors are specific for TNF-RELATED APOPTOSIS-INDUCING LIGAND and signal via conserved death domains that associate with specific TNF RECEPTOR-ASSOCIATED FACTORS in the CYTOPLASM.
Apoptotic Protease-activating Factor 1
A CARD signaling adaptor protein that plays a role in the mitochondria-stimulated apoptosis (APOPTOSIS, INTRINSIC PATHWAY). It binds to CYTOCHROME C in the CYTOSOL to form an APOPTOSOMAL PROTEIN COMPLEX and activates INITIATOR CASPASES such as CASPASE 9.
Receptors, Tumor Necrosis Factor, Member 10c
A secreted tumor necrosis factor receptor family member that has specificity for TNF-RELATED APOPTOSIS-INDUCING LIGAND. It plays a modulating role in activation of APOPTOSIS signaling.
Apoptosomes
Multimeric protein complexes formed in the CYTOSOL that play a role in the activation of APOPTOSIS. They can occur when MITOCHONDRIA become damaged due to cell stress and release CYTOCHROME C. Cytosolic cytochrome C associates with APOPTOTIC PROTEASE-ACTIVATING FACTOR 1 to form the apoptosomal protein complex. The apoptosome signals apoptosis by binding to and activating specific INITIATOR CASPASES such as CASPASE 9.
Cytogenetics
A subdiscipline of genetics which deals with the cytological and molecular analysis of the CHROMOSOMES, and location of the GENES on chromosomes, and the movements of chromosomes during the CELL CYCLE.
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