Halogenation of N(6)-benzyladenosine decreases its cytotoxicity in human leukemia cells.
Summary of "Halogenation of N(6)-benzyladenosine decreases its cytotoxicity in human leukemia cells."
Cytotoxicity of two halogen derivatives of N(6)-benzyladenosine (BAPR), N(6)-(3-iodobenzyl)-adenosine (I-BAPR) and 2-chloro-N(6)-(3-iodobenzyl)-adenosine (Cl-I-BAPR), was tested in human leukemia U937 cell line. Our results revealed that their cytotoxicity was surprisingly low. I-BAPR and also Cl-I-BAPR induced cell death with morphological and biochemical hallmarks of apoptosis, although the number of apoptotic cells was significantly lower than that found for BAPR. Our data strongly suggested that the decreased cytotoxic effect of halogenated derivatives of N(6)-benzyladenosine was related to their reduced intracellular phosphorylation by adenosine kinase.
Department of Biology, Faculty of Medicine and Dentistry, Palacky University in Olomouc, Hnevotinska 3, Olomouc 77515, Czech Republic.
This article was published in the following journal.
Name: Toxicology in vitro : an international journal published in association with BIBRA
- PubMed Source: http://www.ncbi.nlm.nih.gov/pubmed/20637856
- DOI: http://dx.doi.org/10.1016/j.tiv.2010.07.010
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