Halogenation of N(6)-benzyladenosine decreases its cytotoxicity in human leukemia cells.
Summary of "Halogenation of N(6)-benzyladenosine decreases its cytotoxicity in human leukemia cells."
Cytotoxicity of two halogen derivatives of N(6)-benzyladenosine (BAPR), N(6)-(3-iodobenzyl)-adenosine (I-BAPR) and 2-chloro-N(6)-(3-iodobenzyl)-adenosine (Cl-I-BAPR), was tested in human leukemia U937 cell line. Our results revealed that their cytotoxicity was surprisingly low. I-BAPR and also Cl-I-BAPR induced cell death with morphological and biochemical hallmarks of apoptosis, although the number of apoptotic cells was significantly lower than that found for BAPR. Our data strongly suggested that the decreased cytotoxic effect of halogenated derivatives of N(6)-benzyladenosine was related to their reduced intracellular phosphorylation by adenosine kinase.
Affiliation
Department of Biology, Faculty of Medicine and Dentistry, Palacky University in Olomouc, Hnevotinska 3, Olomouc 77515, Czech Republic.
Journal Details
This article was published in the following journal.
Name: Toxicology in vitro : an international journal published in association with BIBRA
ISSN: 1879-3177
Pages:
Links
- PubMed Source: http://www.ncbi.nlm.nih.gov/pubmed/20637856
- DOI: http://dx.doi.org/10.1016/j.tiv.2010.07.010
Medical and Biotech [MESH] Definitions
Kirsten Murine Sarcoma Virus
A replication-defective murine sarcoma virus (SARCOMA VIRUSES, MURINE) capable of transforming mouse lymphoid cells and producing erythroid leukemia after superinfection with murine leukemia viruses (LEUKEMIA VIRUS, MURINE). It has also been found to transform cultured human fibroblasts, rat liver epithelial cells, and rat adrenocortical cells.
Abelson Murine Leukemia Virus
A replication-defective strain of Murine leukemia virus (LEUKEMIA VIRUS, MURINE) capable of transforming lymphoid cells and producing a rapidly progressing lymphoid leukemia after superinfection with FRIEND MURINE LEUKEMIA VIRUS; MOLONEY MURINE LEUKEMIA VIRUS; or RAUSCHER VIRUS.
Philadelphia Chromosome
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Deltaretrovirus
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