Positive reinforcing effects of substance P in the rat globus pallidus revealed by conditioned place preference.
Summary of "Positive reinforcing effects of substance P in the rat globus pallidus revealed by conditioned place preference."
Substance P (SP) may have positive reinforcing effects when injected into different brain structures. Immunohistochemical experiments showed the presence of SP-immunoreactive fibers and also its receptors in the globus pallidus (GP). According to recent experimental data the GP may be involved in reward-related processes. The aim of our study was to test possible rewarding consequences of pallidal SP in conditioned place preference (CPP) paradigm. Male Wistar rats, microinjected with 10ng SP, showed place preference, while 100ng SP had no such positive reinforcing effect. The possible involvement of NK1 receptors was also studied. Prior treatment with the NK1 receptor antagonist WIN 51,708 could block the rewarding effects of SP, while the antagonist on its own did not influence CPP behavior. Our results show that SP and its NK1 receptors play important roles in pallidal positive reinforcing mechanisms.
Affiliation
Neurophysiology Research Group of the Hungarian Academy of Sciences, Pécs, Hungary.
Journal Details
This article was published in the following journal.
Name: Behavioural brain research
ISSN: 1872-7549
Pages: 152-5
Links
- PubMed Source: http://www.ncbi.nlm.nih.gov/pubmed/20600338
- DOI: http://dx.doi.org/10.1016/j.bbr.2010.06.027
Medical and Biotech [MESH] Definitions
Corpus Striatum
Striped gray and white matter consisting of the NEOSTRIATUM and paleostriatum (GLOBUS PALLIDUS). It is located in front of and lateral to the thalamus in each cerebral hemisphere. The gray substance is made up of the CAUDATE NUCLEUS and the lentiform nucleus (the latter consisting of the GLOBUS PALLIDUS and PUTAMEN). The white matter is the internal capsule.
Putamen
The largest and most lateral of the basal ganglia lying between the lateral medullary lamina of the globus pallidus and the external capsule. It is part of the neostriatum and forms part of the lentiform nucleus along with the globus pallidus.
Substantia Innominata
Tissue in the base of the forebrain inferior to the anterior perforated substance, and anterior to the GLOBUS PALLIDUS and ansa lenticularis. It contains the BASAL NUCLEUS OF MEYNERT.
Entopeduncular Nucleus
A portion of the nucleus of ansa lenticularis located medial to the posterior limb of the internal capsule, along the course of the ansa lenticularis and the inferior thalamic peduncle or as a separate nucleus within the internal capsule adjacent to the medial GLOBUS PALLIDUS (NeuroNames, http://rprcsgi.rprc. washington.edu/neuronames/ (September 28, 1998)). In non-primates, the entopeduncular nucleus is analogous to both the medial globus pallidus and the entopeduncular nucleus of human.
Extinction, Psychological
The procedure of presenting the conditioned stimulus without REINFORCEMENT to an organism previously conditioned. It refers also to the diminution of a conditioned response resulting from this procedure.
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