Advertisement

Topics

Robust non-parametric one-sample tests for the analysis of recurrent events.

06:00 EST 21st December 2010 | BioPortfolio

Summary of "Robust non-parametric one-sample tests for the analysis of recurrent events."

One-sample non-parametric tests are proposed here for inference on recurring events. The focus is on the marginal mean function of events and the basis for inference is the standardized distance between the observed and the expected number of events under a specified reference rate. Different weights are considered in order to account for various types of alternative hypotheses on the mean function of the recurrent events process. A robust version and a stratified version of the test are also proposed. The performance of these tests was investigated through simulation studies under various underlying event generation processes, such as homogeneous and nonhomogeneous Poisson processes, autoregressive and renewal processes, with and without frailty effects. The robust versions of the test have been shown to be suitable in a wide variety of event generating processes. The motivating context is a study on gene therapy in a very rare immunodeficiency in children, where a major end-point is the recurrence of severe infections. Robust non-parametric one-sample tests for recurrent events can be useful to assess efficacy and especially safety in non-randomized studies or in epidemiological studies for comparison with a standard population. Copyright © 2010 John Wiley & Sons, Ltd.

Affiliation

Department of Clinical Medicine and Prevention, Center of Biostatistics for Clinical Epidemiology, University of Milano-Bicocca, Via Cadore 48-20052, Monza, Italy. paola.rebora@unimib.it.

Journal Details

This article was published in the following journal.

Name: Statistics in medicine
ISSN: 1097-0258
Pages: 3137-46

Links

DeepDyve research library

PubMed Articles [27851 Associated PubMed Articles listed on BioPortfolio]

Joint frailty models for zero-inflated recurrent events in the presence of a terminal event.

Recurrent event data arise frequently in longitudinal medical studies. In many situations, there are a large portion of subjects without any recurrent events, manifesting the "zero-inflated" nature of...

Utility of a genetic risk score to predict recurrent cardiovascular events 1 year after an acute coronary syndrome: A pooled analysis of the RISCA, PRAXY, and TRIUMPH cohorts.

Limited evidence exists regarding the utility of genetic risk scores (GRS) in predicting recurrent cardiovascular events after acute coronary syndrome (ACS). We sought to determine whether a GRS would...

T test as a parametric statistic.

In statistic tests, the probability distribution of the statistics is important. When samples are drawn from population N (µ, σ(2)) with a sample size of n, the distribution of the sample mean X̄ s...

Score test for association between recurrent events and a terminal event.

The statistical analysis of recurrent events relies on the assumption of independent censoring. When random effects are used, this means, in addition, that the censoring cannot depend on the random ef...

Bayesian analysis of multi-type recurrent events and dependent termination with nonparametric covariate functions.

Multi-type recurrent event data occur frequently in longitudinal studies. Dependent termination may occur when the terminal time is correlated to recurrent event times. In this article, we simultaneou...

Clinical Trials [7170 Associated Clinical Trials listed on BioPortfolio]

Genotype Based Personalized Prescription of Nevirapine

Genetic tests has been suggested to reduce side effects related to Nevirapine(NVP), a commonly prescribed component of highly active antiretroviral therapy(HAART) in developing countries. ...

Salvage Cryotherapy in Recurrent Prostate Cancer

To provide a systemic, uniform and user-friendly tool for collection of data on prostate cancer salvage cryotherapy in a multicenter setting. The goal is to learn more about the short and...

Blood Sample Analysis in Predicting Overall Survival in Patients With Recurrent or Metastatic Head and Neck Cancer

RATIONALE: Studying samples of blood in the laboratory from patients with cancer may help doctors learn more about changes that occur in DNA and identify biomarkers related to cancer. It m...

Cancer Diagnosis by Multiparametric UltraSound of the Prostate (Short- MP-USS Versus MP-MRI for Prostate Cancer Diagnosis)

In men who have had a prior prostate biopsy and who require further risk stratification, does a multi-parametric ultrasound based diagnostic strategy compared to a multi-parametric MRI bas...

Serial mpMRI (Multi Parametric Magnetic Resonance Imaging) Scanning in Prostate Cancer After Androgen Deprivation Therapy and RadioTherapy

The evaluation of the radiological changes in localised or locally advanced prostate cancer after androgen deprivation therapy and external beam radiotherapy using multi-parametric MRI (mu...

Medical and Biotech [MESH] Definitions

The analysis of a chemical substance by inserting a sample into a carrier stream of reagent using a sample injection valve that propels the sample downstream where mixing occurs in a coiled tube, then passes into a flow-through detector and a recorder or other data handling device.

The application of probability and statistical methods to calculate the risk of occurrence of any event, such as onset of illness, recurrent disease, hospitalization, disability, or death. It may include calculation of the anticipated money costs of such events and of the premiums necessary to provide for payment of such costs.

Tests used in the analysis of the hemic system.

Differential thermal analysis in which the sample compartment of the apparatus is a differential calorimeter, allowing an exact measure of the heat of transition independent of the specific heat, thermal conductivity, and other variables of the sample.

Tests based on the biochemistry and physiology of the exocrine pancreas and involving analysis of blood, duodenal contents, feces, or urine for products of pancreatic secretion.

Quick Search
Advertisement
 


DeepDyve research library

Relevant Topics

Gene Therapy
Gene therapy is the use of DNA as a pharmaceutical agent to treat disease. It derives its name from the idea that DNA can be used to supplement or alter genes within an individual's cells as a therapy to treat disease. The most common form of gene th...

Pediatrics
Pediatrics is the general medicine of childhood. Because of the developmental processes (psychological and physical) of childhood, the involvement of parents, and the social management of conditions at home and at school, pediatrics is a specialty. With ...


Searches Linking to this Article