Pharmacokinetics and dosage regimen of ciprofloxacin following single intramuscular administration in teddy goats.
Summary of "Pharmacokinetics and dosage regimen of ciprofloxacin following single intramuscular administration in teddy goats."
The objective of this study was to determine the pharmacokinetics and dosage regimen of ciprofloxacin in Teddy goats. Ciprofloxacin was administered intramuscularly at 5 mg/kg body weight in each of eight animals. Following drug administration, blood samples were collected at different time intervals and analyzed for ciprofloxacin using HPLC. Pharmacokinetic parameters were calculated using two compartment open model. Peak plasma concentration (C(max)) of ciprofloxacin, 1.77 ± 0.20 µg/ml was achieved at 0.90 ± 0.04 hours (T(max)). Values for half-life of absorption (t(1/2)abs), distribution (t(1/2) α) and elimination (t(1/2) β) were 0.52 ± 0.04, 0.52 ± 0.04 and 2.62 ± 0.39 hours, respectively. The value for apparent volume of distribution (Vd) was 3.76 ± 0.92 l/kg, area-under-the-curve (AUC) 5.89 ± 0.91µg.hr/ml and total body clearance (CL) was 1.09 ± 0.11 l/hr/kg. Based on these results, it was concluded that calculated dose should be higher than the dose recommended by the manufacturer to treat susceptible bacteria in goats.
Department of Pharmacology, Isra University, Hyderabad, Pakistan.
This article was published in the following journal.
Name: Pakistan journal of pharmaceutical sciences
Medical and Biotech [MESH] Definitions
Administration of a soluble dosage form by placement under the tongue.
Administration of a soluble dosage form between the cheek and gingiva. It may involve direct application of a drug onto the buccal mucosa, as by painting or spraying.
Forceful administration into a muscle of liquid medication, nutrient, or other fluid through a hollow needle piercing the muscle and any tissue covering it.
The number of copies of a given gene present in the cell of an organism. An increase in gene dosage (by GENE DUPLICATION for example) can result in higher levels of gene product formation. GENE DOSAGE COMPENSATION mechanisms result in adjustments to the level GENE EXPRESSION when there are changes or differences in gene dosage.
The application of suitable drug dosage forms to the skin for either local or systemic effects.
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