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Membranoproliferative glomerulonephritis in a postpartum woman with sickle cell disease.

Summary of "Membranoproliferative glomerulonephritis in a postpartum woman with sickle cell disease."

Renal insufficiency occurs in a considerable proportion of patients with sickle cell disease. Common advanced glomerular lesions include focal segmental glomerulosclerosis and nonimmune membranoproliferative glomerulonephritis. Due to the paucity of data supporting an immune-mediated pathophysiology, anti-inflammatory and immunosuppressive therapies have not been successfully evaluated in such patients. We present a case of membranoproliferative glomerulonephritis in a postpartum patient with sickle cell disease, where treatment with steroids was helpful.

Affiliation

Division of Nephrology, Department of Medicine, University of Connecticut School of Medicine, Farmington, Connecticut, USA. zarjr73@yahoo.com.

Journal Details

This article was published in the following journal.

Name: Iranian journal of kidney diseases
ISSN: 1735-8582
Pages: 63-5

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Medical and Biotech [MESH] Definitions

Chronic glomerulonephritis characterized histologically by proliferation of MESANGIAL CELLS, increase in the MESANGIAL EXTRACELLULAR MATRIX, and a thickening of the glomerular capillary walls. This may appear as a primary disorder or secondary to other diseases including infections and autoimmune disease SYSTEMIC LUPUS ERYTHEMATOSUS. Various subtypes are classified by their abnormal ultrastructures and immune deposits. Hypocomplementemia is a characteristic feature of all types of MPGN.

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Nephrology is a specialty of medicine and pediatrics that concerns itself with the study of normal kidney function, kidney problems, the treatment of kidney problems and renal replacement therapy (dialysis and kidney transplantation). Systemic conditions...