Seven New Monoterpenoid Indole Alkaloids from Gelsemium elegans.
Summary of "Seven New Monoterpenoid Indole Alkaloids from Gelsemium elegans."
Seven new indole alkaloids were isolated from the roots of Gelsemium elegans Benth. and their structures were determined by spectroscopic analysis and chemical transformation from known alkaloids. Kounaminal (1) is a new koumine-type alkaloid that contains an unusual aminal moiety. Humantenoxenine (2) and 15-hydroxyhumantenoxenine (3) are humantenine-type alkaloids that contain a novel β-amino-α,β-unsaturated ketone residue. The other four novel alkaloids are two gelsedilam-related and two gelsenicine-related alkaloids.
Affiliation
Graduate School of Pharmaceutical Sciences, Chiba University, 1-33 Yayoi-cho, Inage-ku, Chiba 263-8522 (Japan), Fax: (+81) 43-290-2901.
Journal Details
This article was published in the following journal.
Name: Chemistry, an Asian journal
ISSN: 1861-471X
Pages: 166-73
Links
- PubMed Source: http://www.ncbi.nlm.nih.gov/pubmed/20960496
- DOI: http://dx.doi.org/10.1002/asia.201000538
Medical and Biotech [MESH] Definitions
Carbazoles
Benzo-indoles similar to CARBOLINES which are pyrido-indoles. In plants, carbazoles are derived from indole and form some of the INDOLE ALKALOIDS.
Indole Alkaloids
Group of alkaloids containing a benzylpyrrole group (derived from TRYPTOPHAN)
Vinca Alkaloids
A group of indole-indoline dimers which are ALKALOIDS obtained from the VINCA genus of plants. They inhibit polymerization of TUBULIN into MICROTUBULES thus blocking spindle formation and arresting cells in METAPHASE. They are some of the most useful ANTINEOPLASTIC AGENTS.
Securidaca
A plant genus of the family POLYGALACEAE that contains securiosides and indole alkaloids.
Psychotria
A plant genus of the family RUBIACEAE. Members contain psychotridine and brachycerine (indole alkaloids).
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