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Pruritus and Atopic Dermatitis.

06:00 EST 6th January 2011 | BioPortfolio

Summary of "Pruritus and Atopic Dermatitis."

Atopic eczema is one of the most pruritic skin diseases. Mediators of atopic eczema itch in the skin are still mostly unknown, but recent studies showed that the histamine 4 receptor plays an important role in itch pathophysiology; tryptase and interleukin-31 are also involved. Differences in itch perception and itch kinetics between healthy volunteers and eczema patients point towards an ongoing central nervous inhibitory activity in patients. Questionnaire studies reported comparatively higher loads in affective items chosen by patients with atopic eczema. In the concept of patient management, the therapy of clinical pruritus has to consider origin and perception of itch, namely the skin and the central nervous system, by combining topical and systemic treatment.

Affiliation

Department of Dermatology and Allergy Biederstein, Technische Universität München, Munich, Germany, ulf.darsow@lrz.tum.de.

Journal Details

This article was published in the following journal.

Name: Clinical reviews in allergy & immunology
ISSN: 1559-0267
Pages:

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Medical and Biotech [MESH] Definitions

The widespread involvement of the skin by a scaly, erythematous dermatitis occurring either as a secondary or reactive process to an underlying cutaneous disorder (e.g., atopic dermatitis, psoriasis, etc.), or as a primary or idiopathic disease. It is often associated with the loss of hair and nails, hyperkeratosis of the palms and soles, and pruritus. (From Dorland, 27th ed)

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