Comparison of Permacol™ and Strattice™ for the repair of abdominal wall defects.
Summary of "Comparison of Permacol™ and Strattice™ for the repair of abdominal wall defects."
BACKGROUND:
Incisional hernias repaired with mesh can be expected have a lower recurrence rate than with primary repair. Biologic implants have replaced synthetic meshes in certain complex settings. We compared two porcine-dermis derived implants-cross-linked Permacol™ biologic implant and non-cross linked Strattice-firm™ tissue matrix-in a ventral hernia animal model. Our hypothesis is that cross-linked biologic implants are remodeled differently and thus behave differently than non-cross-linked biologic implants.
METHODS:
Eighty-nine, female Sprague-Dawley rats had a 3 × 3 cm full-thickness segment of the abdominal wall excised. A 3 × 3 cm biologic mesh, either Permacol™ or Strattice™, was secured and the skin was closed. At 1-, 3-, 6- and 12-month time intervals, rats in each group were sacrificed and the mesh was excised. The number of adhesions, surface area, mesh thickness and tensile strength were determined, and immunohistochemical analysis performed.
RESULTS:
Permacol™ biologic implant maintained thickness while Strattice™ thickness decreased significantly starting at 3 months. Adhesion area and tenacity were not significantly different between Permacol™ and Strattice™ at all time points. The tensile strength of the Permacol™ biologic implant was greater than that of Strattice™ at 3, 6 and 12 months. Migration of host cells and neo-vascularization was observed in both implant groups.
CONCLUSIONS:
Cross-linked materials may prove more durable in the remodeling process as suggested by the increased thinning and weakening observed in non-cross-linked biomesh.
Affiliation
Department of Surgery, University of Minnesota, 420 Harvard St., Minneapolis, MN, 55455, USA, groeh001@umn.edu.
Journal Details
This article was published in the following journal.
Name: Hernia : the journal of hernias and abdominal wall surgery
ISSN: 1248-9204
Pages:
Links
- PubMed Source: http://www.ncbi.nlm.nih.gov/pubmed/21234626
- DOI: http://dx.doi.org/10.1007/s10029-010-0777-6
Medical and Biotech [MESH] Definitions
Bladder Exstrophy
A birth defect in which the URINARY BLADDER is malformed and exposed, inside out, and protruded through the ABDOMINAL WALL. It is caused by closure defects involving the top front surface of the bladder, as well as the lower abdominal wall; SKIN; MUSCLES; and the pubic bone.
Hernia, Abdominal
A protrusion of abdominal structures through the retaining ABDOMINAL WALL. It involves two parts: an opening in the abdominal wall, and a hernia sac consisting of PERITONEUM and abdominal contents. Abdominal hernias include groin hernia (HERNIA, FEMORAL; HERNIA, INGUINAL) and VENTRAL HERNIA.
Abdominal Wall
The outer margins of the ABDOMEN, extending from the osteocartilaginous thoracic cage to the PELVIS. Though its major part is muscular, the abdominal wall consists of at least seven layers: the SKIN, subcutaneous fat, deep FASCIA; ABDOMINAL MUSCLES, transversalis fascia, extraperitoneal fat, and the parietal PERITONEUM.
Abdominal Wound Closure Techniques
Methods to repair breaks in abdominal tissues caused by trauma or to close surgical incisions during abdominal surgery.
Hernia, Ventral
A hernia caused by weakness of the anterior ABDOMINAL WALL due to midline defects, previous incisions, or increased intra-abdominal pressure. Ventral hernias include UMBILICAL HERNIA, incisional, epigastric, and spigelian hernias.
PubMed Articles
PURPOSE: The objective of this study was to evaluate the histologic remodeling profile and biomechanical properties of the porcine abdominal wall after repair with HDMI-crosslinked (Permacol(®)) or n...
BACKGROUND: In laparoscopic incisional hernia repair, direct contact between the prosthesis and the abdominal viscera is inevitable, which may lead to an inflammatory reaction resulting in abdominal a...
An enigma of spontaneous combined transdiaphragmatic, intercostal and abdominal wall hernia.
INTRODUCTION: Cough can be associated with many complications. MATERIALS AND METHODS: We present a 59-year-old male patient with a very rare combination of a cough-related stress fracture of the ninth...
Bacterial clearance of biologic grafts used in hernia repair: an experimental study.
BACKGROUND: Biologic grafts used in ventral hernia repair are derived from various sources and undergo different post-tissue-harvesting processing, handling, and sterilization techniques. It is unclea...
Planned Hernia Repair and Late Abdominal Wall Reconstruction.
Planned ventral hernia is a management strategy in which the abdominal fascial layer has been left unclosed and the viscera are covered only with original or grafted skin. Leaving the fascia open can...
Clinical Trials
Open Mesh Versus Suture Repair in Treatment of Abdominal Wall Hernias
The purpose of this study is to: 1. compare the long term results of mesh versus suture repair in treatment of abdominal wall defects; 2. find the optimal location of impl...
Parastomal Hernia Prevention With Strattice
The purpose of this study is to compare the clinical outcomes of patients undergoing surgery for a permanent abdominal wall ostomy with and without placement of Strattice fascial inlay, as...
COMplete Versus PArtial Open inCisional Hernia Repair (COMPAC-TRIAL)
To compare the complete repair of the abdominal wall at the level of the former incision with only a partial repair at the level of the hernia in patients with an incisional hernia after m...
Trial of Collagen Mesh for Prevention of Ventral Hernia After Surgery for Advanced Pelvic Cancer
The aim of the present project is to investigate whether use of biological mesh at the donor site of the rotation flap in closure of the abdominal wall reduce the frequency of incisional h...
Surgical Study Comparing 2 Procedures for the Treatment of a Dropped Bladder
The purpose of this study is to determine whether vaginal repair or abdominal repair is the procedure of choice for the surgical management of a prolapsed bladder.
