Safety of perioperative β-blocker use: how do β-blockers compare in terms of side effects?
Summary of "Safety of perioperative β-blocker use: how do β-blockers compare in terms of side effects?"
Introduction: In the perioperative setting, there is still a high incidence of adverse cardiac events due to sudden coronary plaque rupture or oxygen supply-demand imbalance. β-Blockers play an important role in preventing these cardiac events. Discussion, however, remains on the side effects accompanying this therapy. Areas covered: The evidence for perioperative use of β-blockers is summarized in this review in terms of risk reduction, perioperative safety and current clinical use. Furthermore, data on pharmacokinetics, pharmacodynamics and pharmacogenetics are presented. Expert opinion: In perioperative care, β-blockers are recommended and can be given safely when started early in a low dose, titrated to heart rate. In the future, there could be a place for added perioperative short-acting β-blockers to further optimize heart rate control.
Affiliation
Erasmus Medical Centre, Department of Vascular Surgery, Suite H 805, 3015 CE, Rotterdam, The Netherlands +0031 10 7034613 ; d.poldermans@erasmusmc.nl.
Journal Details
This article was published in the following journal.
Name: Expert opinion on drug safety
ISSN: 1744-764X
Pages:
Links
- PubMed Source: http://www.ncbi.nlm.nih.gov/pubmed/21247365
- DOI: http://dx.doi.org/10.1517/14740338.2011.552500
Medical and Biotech [MESH] Definitions
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A nicotinic antagonist that is well absorbed from the gastrointestinal tract and crosses the blood-brain barrier. Mecamylamine has been used as a ganglionic blocker in treating hypertension, but, like most ganglionic blockers, is more often used now as a research tool.
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A nicotinic cholinergic antagonist often referred to as the prototypical ganglionic blocker. It is poorly absorbed from the gastrointestinal tract and does not cross the blood-brain barrier. It has been used for a variety of therapeutic purposes including hypertension but, like the other ganglionic blockers, it has been replaced by more specific drugs for most purposes, although it is widely used a research tool.
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