A stochastic multicriteria model for evidence-based decision making in drug benefit-risk analysis.
Summary of "A stochastic multicriteria model for evidence-based decision making in drug benefit-risk analysis."
Drug benefit-risk (BR) analysis is based on firm clinical evidence regarding various safety and efficacy outcomes. In this paper, we propose a new and more formal approach for constructing a supporting multi-criteria model that fully takes into account the evidence on efficacy and adverse drug reactions. Our approach is based on the stochastic multi-criteria acceptability analysis methodology, which allows us to compute the typical value judgments that support a decision, to quantify decision uncertainty, and to compute a comprehensive BR profile. We construct a multi-criteria model for the therapeutic group of second-generation antidepressants. We assess fluoxetine and venlafaxine together with placebo according to incidence of treatment response and three common adverse drug reactions by using data from a published study. Our model shows that there are clear trade-offs among the treatment alternatives. Copyright © 2011 John Wiley & Sons, Ltd.
Affiliation
Econometric Institute, Erasmus University Rotterdam, The Netherlands. tervonen@ese.eur.nl.
Journal Details
This article was published in the following journal.
Name: Statistics in medicine
ISSN: 1097-0258
Pages: 1419-28
Links
- PubMed Source: http://www.ncbi.nlm.nih.gov/pubmed/21268053
- DOI: http://dx.doi.org/10.1002/sim.4194
Medical and Biotech [MESH] Definitions
Decision Support Techniques
Mathematical or statistical procedures used as aids in making a decision. They are frequently used in medical decision-making.
Decision Making, Computer-assisted
Use of an interactive computer system designed to assist the physician or other health professional in choosing between certain relationships or variables for the purpose of making a diagnostic or therapeutic decision.
Decision Support Systems, Clinical
Computer-based information systems used to integrate clinical and patient information and provide support for decision-making in patient care.
Decision Making
The process of making a selective intellectual judgment when presented with several complex alternatives consisting of several variables, and usually defining a course of action or an idea.
Decision Trees
A graphic device used in decision analysis, series of decision options are represented as branches (hierarchical).
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