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Obesity is one of the constellation of factors that make up the definition of the metabolic syndrome. Metabolic syndrome is also associated with insulin resistance, dyslipidemia, hypertriglyceridemia, and type 2 diabetes mellitus. The presence of obesity and metabolic syndrome in men and women is also associated with increased risk of cardiovascular disease and hypertension. In men, obesity and metabolic syndrome are associated with reductions in testosterone levels. In women, obesity and metabolic syndrome are associated with increases in androgen levels. In men, reductions in androgen levels are associated with inflammation, and androgen supplements reduce inflammation. In women, increases in androgens are associated with increases in inflammatory cytokines, and reducing androgens reduces inflammation. This review discusses the possibility that the effects of androgens on metabolic syndrome and its sequelae may differ between males and females.
Women's Health Research Center, University of Mississippi Medical Center, 2500 N. State Street, Jackson, MS, 39216-4505, USA.
This article was published in the following journal.
Name: Current hypertension reports
Metabolic syndrome is a combination of insulin resistance, impaired glucose regulation, dyslipidemia, hypertension, microalbuminuria and obesity and this increases the risk for diabetes, myocardial in...
This review was designed to revaluate the androgen role on the mechanisms of hypertension and cardiovascular risks in both men and women. Sex steroids are involved in the regulation of blood pressure,...
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To determine if a one year treatment Losartan with or without HCTZ at different dosages have an effect on metabolic parameters in patients with hypertension and the metabolic syndrome.
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Nonsteroidal agents which block the action or downregulate the synthesis of ANDROGENS.
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