Serotonin, depression, and cardiovascular disease: sex-specific issues.
Summary of "Serotonin, depression, and cardiovascular disease: sex-specific issues."
The comorbidity of cardiovascular disease (CVD) and depression/anxiety disorders is well established, but the mechanisms are not well understood. This paper will review the epidemiological and biological evidence for the role of depression in CVD, as well as the pathophysiological process underlying both depression and CVD. The focus will be on the roles of serotonin, platelets, and the immune system, with an emphasis on the relevance of sex differences in both depression/anxiety and CVD as they pertain to women.
Women's Health Concerns Clinic, St. Joseph's Healthcare, Hamilton, ON, Canada; Departments of Psychiatry & Behavioural Neurosciences and Obstetrics & Gynecology, McMaster University, Hamilton, ON, Canada; and Department of Psychiatry and Institute of Medi
This article was published in the following journal.
Name: Acta physiologica (Oxford, England)
- PubMed Source: http://www.ncbi.nlm.nih.gov/pubmed/21281455
- DOI: http://dx.doi.org/10.1111/j.1748-1716.2010.02236.x
Medical and Biotech [MESH] Definitions
Receptor, Serotonin, 5-ht1a
A serotonin receptor subtype found distributed through the CENTRAL NERVOUS SYSTEM where they are involved in neuroendocrine regulation of ACTH secretion. The fact that this serotonin receptor subtype is particularly sensitive to SEROTONIN AGONISTS such as BUSPIRONE suggests its role in the modulation of ANXIETY and DEPRESSION.
Serotonin Uptake Inhibitors
Compounds that specifically inhibit the reuptake of serotonin in the brain. This increases the serotonin concentration in the synaptic cleft which then activates serotonin receptors to a greater extent. These agents have been used in treatment of depression, panic disorder, obsessive-compulsive behavior, and alcoholism, as analgesics, and to treat obesity and bulimia. Many of the ADRENERGIC UPTAKE INHIBITORS also inhibit serotonin uptake; they are not included here.
Serotonin 5-ht2 Receptor Antagonists
Drugs that bind to but do not activate SEROTONIN 5-HT2 RECEPTORS, thereby blocking the actions of SEROTONIN or SEROTONIN 5-HT2 RECEPTOR AGONISTS. Included under this heading are antagonists for one or more specific 5-HT2 receptor subtypes.
Pregnancy Complications, Cardiovascular
The co-occurrence of pregnancy and a cardiovascular disease. The disease may precede or follow FERTILIZATION and it may or may not have a deleterious effect on the pregnant woman or FETUS.
A biochemical messenger and regulator, synthesized from the essential amino acid L-TRYPTOPHAN. In humans it is found primarily in the central nervous system, gastrointestinal tract, and blood platelets. Serotonin mediates several important physiological functions including neurotransmission, gastrointestinal motility, hemostasis, and cardiovascular integrity. Multiple receptor families (RECEPTORS, SEROTONIN) explain the broad physiological actions and distribution of this biochemical mediator.
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