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Somatic and autonomic small fiber neuropathy induced by bortezomib therapy: an immunofluorescence study.

08:24 EDT 28th July 2014 | BioPortfolio

Summary of "Somatic and autonomic small fiber neuropathy induced by bortezomib therapy: an immunofluorescence study."

Bortezomib is a new chemotherapeutic agent approved for the treatment of relapsed/refractory and newly diagnosed multiple myeloma. One of the major side effects of bortezomib is a peripheral length-dependent sensory axonal neuropathy and, less frequently, a small fiber neuropathy. Autonomic symptoms like postural dizziness, syncope, diarrhoea, ileus, impotence and urinary disturbances have been reported, nevertheless, autonomic neuropathy has never been characterized. We describe by means of immunofluorescence, the involvement of autonomic skin nerve fibers in three patients with small fiber neuropathy induced by bortezomib treatment.

Affiliation

Dipartimento di Scienze Neurologiche, Università di Bologna, Via Ugo, Foscolo 7, 40123, Bologna, Italy, mpgiannoccaro@gmail.com.

Journal Details

This article was published in the following journal.

Name: Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiol
ISSN: 1590-3478
Pages:

Links

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Medical and Biotech [MESH] Definitions

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A TEXTILE fiber obtained from the pappus (outside the SEEDS) of cotton plant (GOSSYPIUM). Inhalation of cotton fiber dust over a prolonged period can result in BYSSINOSIS.

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